FZD10

Frizzled homolog 10 (Drosophila)
Identifiers
Symbol(s)	FZD10; FZ-10; FzE7; hFz10
External IDs	OMIM: 606147 MGI: 2136761 Homologene: 21411
Gene ontology Molecular Function: • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • Wnt receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	11211	93897
Ensembl	ENSG00000111432	na
Uniprot	Q9ULW2	na
Refseq	NM_007197 (mRNA) NP_009128 (protein)	XM_974070 (mRNA) XP_979164 (protein)
Location	Chr 12: 129.21 - 129.22 Mb	na
Pubmed search	[1]	[2]

Frizzled homolog 10 (Drosophila), also known as FZD10, is a human gene. FZD10 has also been designated as CD350 (cluster of differentiation 350).

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer.

See also

• Frizzled

Further reading

• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770-5. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164-9. PMID 9707618.
• Koike J, Takagi A, Miwa T, et al. (1999). "Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family.". Biochem. Biophys. Res. Commun. 262 (1): 39-43. doi:10.1006/bbrc.1999.1161. PMID 10448064.
• Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.". Osteoarthr. Cartil. 9 (7): 641-53. doi:10.1053/joca.2001.0421. PMID 11597177.
• Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). "Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway.". Int. J. Mol. Med. 9 (2): 107-12. PMID 11786918.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81-90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

External links

• MeSH FZD10+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.