Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2
Identifiers
Symbol(s)	HCRTR2; OX2R
External IDs	OMIM: 602393 MGI: 2680765 Homologene: 1168
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • neuropeptide receptor activity • orexin receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • neuropeptide signaling pathway • synaptic transmission • feeding behavior
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3062	387285
Ensembl	ENSG00000137252	ENSMUSG00000032360
Uniprot	O43614	Q8BV78
Refseq	NM_001526 (mRNA) NP_001517 (protein)	NM_198962 (mRNA) NP_945200 (protein)
Location	Chr 6: 55.15 - 55.26 Mb	Chr 9: 76.01 - 76.11 Mb
Pubmed search	[1]	[2]

Hypocretin (orexin) receptor 2, also known as HCRTR2, is a human gene.

HCRTR2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with HCRTR1. HCRTR2 binds both orexin A and orexin B neuropeptides. HCRTR2 is involved in the central feedback mechanism that regulates feeding behaviour.

See also

• Orexin receptor

Further reading

• Flier JS, Maratos-Flier E (1998). "Obesity and the hypothalamus: novel peptides for new pathways.". Cell 92 (4): 437-40. PMID 9491885.
• Willie JT, Chemelli RM, Sinton CM, Yanagisawa M (2001). "To eat or to sleep? Orexin in the regulation of feeding and wakefulness.". Annu. Rev. Neurosci. 24: 429-58. doi:10.1146/annurev.neuro.24.1.429. PMID 11283317.
• Hungs M, Mignot E (2001). "Hypocretin/orexin, sleep and narcolepsy.". Bioessays 23 (5): 397-408. doi:10.1002/bies.1058. PMID 11340621.
• de Lecea L, Kilduff TS, Peyron C, et al. (1998). "The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 322-7. PMID 9419374.
• Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (4): 573-85. PMID 9491897.
• Sakurai T, Amemiya A, Ishii M, et al. (1998). "Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.". Cell 92 (5): 1 page following 696. PMID 9527442.
• Peyron C, Faraco J, Rogers W, et al. (2000). "A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains.". Nat. Med. 6 (9): 991-7. doi:10.1038/79690. PMID 10973318.
• Wright GJ, Puklavec MJ, Willis AC, et al. (2000). "Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.". Immunity 13 (2): 233-42. PMID 10981966.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863.
• Mazzocchi G, Malendowicz LK, Gottardo L, et al. (2001). "Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade.". J. Clin. Endocrinol. Metab. 86 (2): 778-82. PMID 11158046.
• Blanco M, López M, García-Caballero T, et al. (2001). "Cellular localization of orexin receptors in human pituitary.". J. Clin. Endocrinol. Metab. 86 (4): 1616-9. PMID 11297593.
• Blanco M, López M, GarcIa-Caballero T, et al. (2001). "Cellular localization of orexin receptors in human pituitary.". J. Clin. Endocrinol. Metab. 86 (7): 1616-9. PMID 11443222.
• Karteris E, Randeva HS, Grammatopoulos DK, et al. (2001). "Expression and coupling characteristics of the CRH and orexin type 2 receptors in human fetal adrenals.". J. Clin. Endocrinol. Metab. 86 (9): 4512-9. PMID 11549701.
• Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW (2001). "Expression of orexin-A and functional orexin type 2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis.". J. Clin. Endocrinol. Metab. 86 (10): 4808-13. PMID 11600545.
• Olafsdóttir BR, Rye DB, Scammell TE, et al. (2002). "Polymorphisms in hypocretin/orexin pathway genes and narcolepsy.". Neurology 57 (10): 1896-9. PMID 11723285.
• Blanco M, García-Caballero T, Fraga M, et al. (2002). "Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas.". Regul. Pept. 104 (1-3): 161-5. PMID 11830291.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.