Tachykinin receptor 3

Tachykinin receptor 3
Identifiers
Symbol(s)	TACR3; MGC148060; MGC148061; NK3R; TAC3RL
External IDs	OMIM: 162332 MGI: 892968 Homologene: 824
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • tachykinin receptor activity Cellular Component: • plasma membrane • integral to plasma membrane Biological Process: • signal transduction • tachykinin signaling pathway
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6870	21338
Ensembl	ENSG00000169836	ENSMUSG00000028172
Uniprot	P29371	Q6NXX1
Refseq	NM_001059 (mRNA) NP_001050 (protein)	NM_021382 (mRNA) NP_067357 (protein)
Location	Chr 4: 104.73 - 104.86 Mb	Chr 3: 134.77 - 134.87 Mb
Pubmed search	[1]	[2]

Tachykinin receptor 3, also known as TACR3, is a human gene.

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.

See also

• Tachykinin receptor

Further reading

• Khawaja AM, Rogers DF (1996). "Tachykinins: receptor to effector.". Int. J. Biochem. Cell Biol. 28 (7): 721-38. PMID 8925404.
• Advenier C, Lagente V, Boichot E (1997). "The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough.". Eur. Respir. J. 10 (8): 1892-906. PMID 9272936.
• Buell G, Schulz MF, Arkinstall SJ, et al. (1992). "Molecular characterisation, expression and localisation of human neurokinin-3 receptor.". FEBS Lett. 299 (1): 90-5. PMID 1312036.
• Takahashi K, Tanaka A, Hara M, Nakanishi S (1992). "The primary structure and gene organization of human substance P and neuromedin K receptors.". Eur. J. Biochem. 204 (3): 1025-33. PMID 1312928.
• Xie GX, Miyajima A, Goldstein A (1992). "Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 4124-8. PMID 1315051.
• Huang RR, Cheung AH, Mazina KE, et al. (1992). "cDNA sequence and heterologous expression of the human neurokinin-3 receptor.". Biochem. Biophys. Res. Commun. 184 (2): 966-72. PMID 1374246.
• Dion S, Corcos J, Carmel M, et al. (1988). "Substance P and neurokinins as stimulants of the human isolated urinary bladder.". Neuropeptides 11 (2): 83-7. PMID 2452993.
• Krause JE, Staveteig PT, Mentzer JN, et al. (1997). "Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H]senktide and [125I-MePhe7]neurokinin B, and is responsive to tachykinin peptide agonists.". Proc. Natl. Acad. Sci. U.S.A. 94 (1): 310-5. PMID 8990205.
• Brunelleschi S, Bordin G, Colangelo D, Viano I (1999). "Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis.". Neuropeptides 32 (3): 215-23. PMID 10189055.
• Page NM, Woods RJ, Gardiner SM, et al. (2000). "Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.". Nature 405 (6788): 797-800. doi:10.1038/35015579. PMID 10866201.
• Bellucci F, Carini F, Catalani C, et al. (2002). "Pharmacological profile of the novel mammalian tachykinin, hemokinin 1.". Br. J. Pharmacol. 135 (1): 266-74. doi:10.1038/sj.bjp.0704443. PMID 11786503.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Graham GJ, Stevens JM, Page NM, et al. (2005). "Tachykinins regulate the function of platelets.". Blood 104 (4): 1058-65. doi:10.1182/blood-2003-11-3979. PMID 15130944.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Page NM, Dakour J, Morrish DW (2006). "Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia.". Mol. Hum. Reprod. 12 (7): 427-33. doi:10.1093/molehr/gal025. PMID 16709596.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.