Trace amine-associated receptor
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Trace amine-associated receptors, abbreviated TAAR and previously abbreviated TAR and TA, are a class of G protein-coupled receptors identified in 2001.[1]
These receptors have gained considerable interest in academic and pharmaceutical industry research as putative endogenous receptors for trace amines, metabolic derivatives of classical biogenic amines.[2][3][4]
In 2006 it was shown that TAAR1 is most probably a receptor for thyronamines, decarboxylated and deiodinated metabolites of the thyroid hormones, while the mouse mTAAR2 - mTAAR9 receptors are most probably olfactory receptors for volatile amines.[5]
Contents |
Mammalian TAAR complement
- Rat genome—17 genes and 2 pseudogenes
- Mouse genome—15 genes and 1 pseudogene
- Human genome— 7 genes (TAAR1, TAAR2, TAAR3, TAAR5, TAAR6, TAAR8, TAAR9) and 2 pseudogenes (TAAR4P, TAAR7P)
- Chimpanzee genome—3 genes and 6 pseudogenes
See also
External links
References
- ↑ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966-71. doi:10.1073/pnas.151105198. PMID 11459929.
- ↑ Lindemann L, Hoener MC (2005). "A renaissance in trace amines inspired by a novel GPCR family". Trends Pharmacol. Sci. 26 (5): 274-81. doi:10.1016/j.tips.2005.03.007. PMID 15860375.
- ↑ Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK (2004). "3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone". Nat. Med. 10 (6): 638-42. doi:10.1038/nm1051. PMID 15146179.
- ↑ Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS (2006). "Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues". J. Med. Chem. 49 (3): 1101-12. doi:10.1021/jm0505718. PMID 16451074.
- ↑ Liberles SD, Buck LB (2006). "A second class of chemosensory receptors in the olfactory epithelium". Nature 442 (7103): 645-50. doi:10.1038/nature05066. PMID 16878137.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
