CD97

CD97 molecule
PDB rendering based on 2bo2.
Available structures: 2bo2, 2bou, 2box
Identifiers
Symbol(s)	CD97; TM7LN1
External IDs	OMIM: 601211 MGI: 1347095 Homologene: 8050
Gene ontology Molecular Function: • G-protein coupled receptor activity • calcium ion binding • protein binding Cellular Component: • plasma membrane • integral to plasma membrane Biological Process: • cell motility • inflammatory response • immune response • cell adhesion • neuropeptide signaling pathway • cell-cell signaling
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	976	26364
Ensembl	ENSG00000123146	ENSMUSG00000002885
Uniprot	P48960	Q9Z0M6
Refseq	NM_001025160 (mRNA) NP_001020331 (protein)	NM_011925 (mRNA) NP_036055 (protein)
Location	Chr 19: 14.35 - 14.38 Mb	Chr 8: 86.61 - 86.63 Mb
Pubmed search	[1]	[2]

CD97 molecule, also known as CD97, is a human gene.

This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.

Further reading

• Kwakkenbos MJ, Kop EN, Stacey M, et al. (2004). "The EGF-TM7 family: a postgenomic view.". Immunogenetics 55 (10): 655-66. doi:10.1007/s00251-003-0625-2. PMID 14647991.
• Hamann J, Eichler W, Hamann D, et al. (1995). "Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain.". J. Immunol. 155 (4): 1942-50. PMID 7636245.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
• Hamann J, Hartmann E, van Lier RA (1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily.". Genomics 32 (1): 144-7. doi:10.1006/geno.1996.0092. PMID 8786105.
• Gray JX, Haino M, Roth MJ, et al. (1997). "CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation.". J. Immunol. 157 (12): 5438-47. PMID 8955192.
• Hamann J, Vogel B, van Schijndel GM, van Lier RA (1997). "The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF).". J. Exp. Med. 184 (3): 1185-9. PMID 9064337.
• Aust G, Eichler W, Laue S, et al. (1997). "CD97: a dedifferentiation marker in human thyroid carcinomas.". Cancer Res. 57 (9): 1798-806. PMID 9135025.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
• Ghannadan M, Baghestanian M, Wimazal F, et al. (1998). "Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies.". J. Invest. Dermatol. 111 (4): 689-95. doi:10.1046/j.1523-1747.1998.00359.x. PMID 9764855.
• Qian YM, Haino M, Kelly K, Song WC (1999). "Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55).". Immunology 98 (2): 303-11. PMID 10540231.
• Eichler W (2000). "CD97 isoform expression in leukocytes.". J. Leukoc. Biol. 68 (4): 561-7. PMID 11037979.
• Lin HH, Stacey M, Saxby C, et al. (2001). "Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex.". J. Biol. Chem. 276 (26): 24160-9. doi:10.1074/jbc.M101770200. PMID 11297558.
• Jaspars LH, Vos W, Aust G, et al. (2001). "Tissue distribution of the human CD97 EGF-TM7 receptor.". Tissue Antigens 57 (4): 325-31. PMID 11380941.
• Steinert M, Wobus M, Boltze C, et al. (2002). "Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues.". Am. J. Pathol. 161 (5): 1657-67. PMID 12414513.
• Visser L, de Vos AF, Hamann J, et al. (2003). "Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis.". J. Neuroimmunol. 132 (1-2): 156-63. PMID 12417446.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Stacey M, Chang GW, Davies JQ, et al. (2003). "The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.". Blood 102 (8): 2916-24. doi:10.1182/blood-2002-11-3540. PMID 12829604.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529-35. doi:10.1038/nature02399. PMID 15057824.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub