5-HT7 receptor

	5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)
	Identifiers
Symbol(s)	HTR7; 5-HT7
External IDs	OMIM: 182137 MGI: 99841 Homologene: 20244
Gene ontology
Molecular Function:	• rhodopsin-like receptor activity; • receptor activity; • melanocortin receptor activity; • serotonin receptor activity;
Cellular Component:	• integral to plasma membrane; • membrane; • integral to membrane;
Biological Process:	• signal transduction; • G-protein coupled receptor protein signaling pathway; • G-protein signaling, coupled to cyclic nucleotide second messenger; • synaptic transmission; • circadian rhythm; • circulation;
	RNA expression pattern
	More reference expression data
	Orthologs

The correct title of this article is 5-HT₇ receptor. It appears incorrectly here because of technical restrictions.

5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled), also known as HTR7, is a human gene.^[1]

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends.^[1]

Ligands

There are several ligands that binds to the 5-HT₇ receptor

N-(1,2,3,4-Tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides^[2]
8-OH-DPAT (5-HT_1A/7 agonist)^[3]
SB-269970 (antagonist)^[4]

References

↑ ^1.0 ^1.1 Entrez Gene: HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled).
↑ Leopoldo M, Lacivita E, Contino M, Colabufo NA, Berardi F, Perrone R (2007). "Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT₇ receptor agents. 2". J. Med. Chem. 50 (17): 4214–21. doi:10.1021/jm070487n. PMID 17649988.
↑ Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (2004). "8-OH-DPAT as a 5-HT₇ agonist: phase shifts of the circadian biological clock through increases in cAMP production". Neuropharmacology 46 (1): 52–62. doi:10.1016/j.neuropharm.2003.08.007. PMID 14654097.
↑ P. J. Lovell et al. (2000). "A novel, potent, and selective 5-HT₇ antagonist : (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)". Journal of Medicinal Chemistry 43 (3): 342–345. PMID 10669560.

Hoyer D, Hannon JP, Martin GR (2002). "Molecular, pharmacological and functional diversity of 5-HT receptors.". Pharmacol. Biochem. Behav. 71 (4): 533-54. PMID 11888546.
Raymond JR, Mukhin YV, Gelasco A, et al. (2002). "Multiplicity of mechanisms of serotonin receptor signal transduction.". Pharmacol. Ther. 92 (2-3): 179-212. PMID 11916537.
Gelernter J, Rao PA, Pauls DL, et al. (1995). "Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome.". Genomics 26 (2): 207-9. PMID 7601444.
Ullmer C, Schmuck K, Kalkman HO, Lübbert H (1995). "Expression of serotonin receptor mRNAs in blood vessels.". FEBS Lett. 370 (3): 215-21. PMID 7656980.
Bard JA, Zgombick J, Adham N, et al. (1993). "Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.". J. Biol. Chem. 268 (31): 23422-6. PMID 8226867.
Lovenberg TW, Baron BM, de Lecea L, et al. (1993). "A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms.". Neuron 11 (3): 449-58. PMID 8398139.
Heidmann DE, Metcalf MA, Kohen R, Hamblin MW (1997). "Four 5-hydroxytryptamine7 (5-HT7) receptor isoforms in human and rat produced by alternative splicing: species differences due to altered intron-exon organization.". J. Neurochem. 68 (4): 1372-81. PMID 9084407.
Erdmann J, Nöthen MM, Shimron-Abarbanell D, et al. (1997). "The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder.". Mol. Psychiatry 1 (5): 392-7. PMID 9154233.
Jasper JR, Kosaka A, To ZP, et al. (1997). "Cloning, expression and pharmacology of a truncated splice variant of the human 5-HT7 receptor (h5-HT7b).". Br. J. Pharmacol. 122 (1): 126-32. doi:10.1038/sj.bjp.0701336. PMID 9298538.
Lassig JP, Vachirasomtoon K, Hartzell K, et al. (1999). "Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder.". Am. J. Med. Genet. 88 (5): 472-5. PMID 10490701.
Krobert KA, Levy FO (2002). "The human 5-HT7 serotonin receptor splice variants: constitutive activity and inverse agonist effects.". Br. J. Pharmacol. 135 (6): 1563-71. doi:10.1038/sj.bjp.0704588. PMID 11906971.
Norum JH, Hart K, Levy FO (2003). "Ras-dependent ERK activation by the human G(s)-coupled serotonin receptors 5-HT4(b) and 5-HT7(a).". J. Biol. Chem. 278 (5): 3098-104. doi:10.1074/jbc.M206237200. PMID 12446729.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Slominski A, Pisarchik A, Zbytek B, et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin.". J. Cell. Physiol. 196 (1): 144-53. doi:10.1002/jcp.10287. PMID 12767050.
Simonin F, Karcher P, Boeuf JJ, et al. (2004). "Identification of a novel family of G protein-coupled receptor associated sorting proteins.". J. Neurochem. 89 (3): 766-75. doi:10.1111/j.1471-4159.2004.02411.x. PMID 15086532.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Brüss M, Kiel S, Bönisch H, et al. (2005). "Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor.". Neurochem. Int. 47 (3): 196-203. doi:10.1016/j.neuint.2005.03.003. PMID 15896881.
Ikeda M, Iwata N, Kitajima T, et al. (2006). "Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population.". Neuropsychopharmacology 31 (4): 866-71. doi:10.1038/sj.npp.1300901. PMID 16192982.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub

[entrez-0] 1.0 ^1.1 Entrez Gene: HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled).

[pmid17649988-1] Leopoldo M, Lacivita E, Contino M, Colabufo NA, Berardi F, Perrone R (2007). "Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT₇ receptor agents. 2". J. Med. Chem. 50 (17): 4214–21. doi:10.1021/jm070487n. PMID 17649988.

[pmid14654097-2] Sprouse J, Reynolds L, Li X, Braselton J, Schmidt A (2004). "8-OH-DPAT as a 5-HT₇ agonist: phase shifts of the circadian biological clock through increases in cAMP production". Neuropharmacology 46 (1): 52–62. doi:10.1016/j.neuropharm.2003.08.007. PMID 14654097.

[3] P. J. Lovell et al. (2000). "A novel, potent, and selective 5-HT₇ antagonist : (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)". Journal of Medicinal Chemistry 43 (3): 342–345. PMID 10669560.

[1]

[2]

[3]

[4]

v • d • e Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

5-HT7 receptor

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