Relaxin/insulin-like family peptide receptor 3

Relaxin/insulin-like family peptide receptor 3
Identifiers
Symbol(s)	RXFP3; GPCR135; MGC141998; MGC142000; RLN3R1; SALPR
External IDs	OMIM: 609445 MGI: 2441827 Homologene: 9568
Gene ontology Molecular Function: • receptor activity • N-formyl peptide receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	51289	239336
Ensembl	ENSG00000182631	ENSMUSG00000060735
Uniprot	Q9NSD7	Q5Y988
Refseq	NM_016568 (mRNA) NP_057652 (protein)	NM_178717 (mRNA) NP_848832 (protein)
Location	Chr 5: 33.97 - 33.97 Mb	Chr 15: 10.98 - 10.98 Mb
Pubmed search	[1]	[2]

Relaxin/insulin-like family peptide receptor 3, also known as RXFP3, is a human gene.

See also

• Relaxin receptor

Further reading

• Bathgate RA, Ivell R, Sanborn BM, et al. (2005). "Receptors for relaxin family peptides.". Ann. N. Y. Acad. Sci. 1041: 61-76. doi:10.1196/annals.1282.010. PMID 15956688.
• Bathgate RA, Ivell R, Sanborn BM, et al. (2006). "International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides.". Pharmacol. Rev. 58 (1): 7-31. doi:10.1124/pr.58.1.9. PMID 16507880.
• Matsumoto M, Kamohara M, Sugimoto T, et al. (2000). "The novel G-protein coupled receptor SALPR shares sequence similarity with somatostatin and angiotensin receptors.". Gene 248 (1-2): 183-9. PMID 10806363.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Liu C, Eriste E, Sutton S, et al. (2004). "Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135.". J. Biol. Chem. 278 (50): 50754-64. doi:10.1074/jbc.M308995200. PMID 14522968.
• Liu C, Chen J, Kuei C, et al. (2005). "Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7.". Mol. Pharmacol. 67 (1): 231-40. doi:10.1124/mol.104.006700. PMID 15465925.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Van der Westhuizen ET, Sexton PM, Bathgate RA, Summers RJ (2005). "Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry.". Ann. N. Y. Acad. Sci. 1041: 332-7. doi:10.1196/annals.1282.053. PMID 15956730.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.