GPR15

G protein-coupled receptor 15
Identifiers
Symbol(s)	GPR15; MGC126828; MGC126830
External IDs	OMIM: 601166 MGI: 1918473 Homologene: 3869
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2838	71223
Ensembl	ENSG00000154165	ENSMUSG00000047293
Uniprot	P49685	na
Refseq	NM_005290 (mRNA) NP_005281 (protein)	XM_001002039 (mRNA) XP_001002039 (protein)
Location	Chr 3: 99.73 - 99.73 Mb	Chr 16: 58.66 - 58.66 Mb
Pubmed search	[1]	[2]

G protein-coupled receptor 15, also known as GPR15, is a human gene.

Further reading

• Cunningham AL, Li S, Juarez J, et al. (2000). "The level of HIV infection of macrophages is determined by interaction of viral and host cell genotypes.". J. Leukoc. Biol. 68 (3): 311-7. PMID 10985245.
• Heiber M, Marchese A, Nguyen T, et al. (1997). "A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.". Genomics 32 (3): 462-5. doi:10.1006/geno.1996.0143. PMID 8838812.
• Deng HK, Unutmaz D, KewalRamani VN, Littman DR (1997). "Expression cloning of new receptors used by simian and human immunodeficiency viruses.". Nature 388 (6639): 296-300. doi:10.1038/40894. PMID 9230441.
• Farzan M, Choe H, Martin K, et al. (1997). "Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.". J. Exp. Med. 186 (3): 405-11. PMID 9236192.
• Clayton F, Kotler DP, Kuwada SK, et al. (2001). "Gp120-induced Bob/GPR15 activation: a possible cause of human immunodeficiency virus enteropathy.". Am. J. Pathol. 159 (5): 1933-9. PMID 11696454.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Croitoru-Lamoury J, Guillemin GJ, Boussin FD, et al. (2003). "Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation.". Glia 41 (4): 354-70. doi:10.1002/glia.10181. PMID 12555203.
• Maresca M, Mahfoud R, Garmy N, et al. (2003). "The virotoxin model of HIV-1 enteropathy: involvement of GPR15/Bob and galactosylceramide in the cytopathic effects induced by HIV-1 gp120 in the HT-29-D4 intestinal cell line.". J. Biomed. Sci. 10 (1): 156-66. doi:10.1159/000068089. PMID 12566994.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Blaak H, Boers PH, Gruters RA, et al. (2005). "CCR5, GPR15, and CXCR6 are major coreceptors of human immunodeficiency virus type 2 variants isolated from individuals with and without plasma viremia.". J. Virol. 79 (3): 1686-700. doi:10.1128/JVI.79.3.1686-1700.2005. PMID 15650194.
• Cilliers T, Willey S, Sullivan WM, et al. (2005). "Use of alternate coreceptors on primary cells by two HIV-1 isolates.". Virology 339 (1): 136-44. doi:10.1016/j.virol.2005.05.027. PMID 15992849.