Dopamine receptor D5

The correct title of this article is Dopamine receptor D₅. It appears incorrectly here because of technical restrictions.

Dopamine receptor D5
Identifiers
Symbol(s)	DRD5; DBDR; DRD1B; DRD1L2; MGC10601
External IDs	OMIM: 126453 MGI: 94927 Homologene: 20216
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • dopamine receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • dopamine receptor, adenylate cyclase activating pathway • synaptic transmission
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	1816	13492
Ensembl	ENSG00000169676	ENSMUSG00000039358
Uniprot	P21918	Q8BLD9
Refseq	NM_000798 (mRNA) NP_000789 (protein)	NM_013503 (mRNA) NP_038531 (protein)
Location	Chr 4: 9.39 - 9.39 Mb	Chr 5: 38.61 - 38.61 Mb
Pubmed search	[1]	[2]

Dopamine receptor D₅, also known as DRD5, is a human gene.

This gene encodes the D₅ subtype of the dopamine receptor. The D₅ subtype is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D₁ subtype. Pseudogenes related to this gene reside on chromosomes 1 and 2.

Ligands

• 4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol: antagonist, moderate binding selectivity over D₁

File:4-Chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz-d,g-azecin-3-ol.png

Chemical structure of a D₅-prefering ligand 4-chloro-7-methyl-5,6,7,8,9,14-hexahydrodibenz[d,g]azecin-3-ol.

See also

• Dopamine receptor

Further reading

• Missale C, Nash SR, Robinson SW, et al. (1998). "Dopamine receptors: from structure to function.". Physiol. Rev. 78 (1): 189-225. PMID 9457173.
• Grandy DK, Allen LJ, Zhang Y, et al. (1992). "Chromosomal localization of three human D5 dopamine receptor genes.". Genomics 13 (4): 968-73. PMID 1387108.
• Eubanks JH, Altherr M, Wagner-McPherson C, et al. (1992). "Localization of the D5 dopamine receptor gene to human chromosome 4p15.1-p15.3, centromeric to the Huntington's disease locus.". Genomics 12 (3): 510-6. PMID 1532789.
• Polymeropoulos MH, Xiao H, Merril CR (1992). "The human D5 dopamine receptor (DRD5) maps on chromosome 4.". Genomics 11 (3): 777-8. PMID 1774076.
• Sunahara RK, Guan HC, O'Dowd BF, et al. (1991). "Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1.". Nature 350 (6319): 614-9. doi:10.1038/350614a0. PMID 1826762.
• Tiberi M, Jarvie KR, Silvia C, et al. (1991). "Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7491-5. PMID 1831904.
• Grandy DK, Zhang YA, Bouvier C, et al. (1991). "Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.". Proc. Natl. Acad. Sci. U.S.A. 88 (20): 9175-9. PMID 1833775.
• Weinshank RL, Adham N, Macchi M, et al. (1991). "Molecular cloning and characterization of a high affinity dopamine receptor (D1 beta) and its pseudogene.". J. Biol. Chem. 266 (33): 22427-35. PMID 1834671.
• Sobell JL, Lind TJ, Sigurdson DC, et al. (1995). "The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease.". Hum. Mol. Genet. 4 (4): 507-14. PMID 7633397.
• Beischlag TV, Marchese A, Meador-Woodruff JH, et al. (1995). "The human dopamine D5 receptor gene: cloning and characterization of the 5'-flanking and promoter region.". Biochemistry 34 (17): 5960-70. PMID 7727453.
• Sherrington R, Mankoo B, Attwood J, et al. (1994). "Cloning of the human dopamine D5 receptor gene and identification of a highly polymorphic microsatellite for the DRD5 locus that shows tight linkage to the chromosome 4p reference marker RAF1P1.". Genomics 18 (2): 423-5. doi:10.1006/geno.1993.1489. PMID 8288248.
• Sidhu A, Kimura K, Uh M, et al. (1998). "Multiple coupling of human D5 dopamine receptors to guanine nucleotide binding proteins Gs and Gz.". J. Neurochem. 70 (6): 2459-67. PMID 9603210.
• Cargill M, Altshuler D, Ireland J, et al. (1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes.". Nat. Genet. 22 (3): 231-8. doi:10.1038/10290. PMID 10391209.
• Liu F, Wan Q, Pristupa ZB, et al. (2000). "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors.". Nature 403 (6767): 274-80. doi:10.1038/35002014. PMID 10659839.
• Misbahuddin A, Placzek MR, Chaudhuri KR, et al. (2004). "A polymorphism in the dopamine receptor DRD5 is associated with blepharospasm.". Neurology 58 (1): 124-6. PMID 11781417.
• Kabbani N, Negyessy L, Lin R, et al. (2002). "Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor.". J. Neurosci. 22 (19): 8476-86. PMID 12351722.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Hemby SE, Trojanowski JQ, Ginsberg SD (2003). "Neuron-specific age-related decreases in dopamine receptor subtype mRNAs.". J. Comp. Neurol. 456 (2): 176-83. doi:10.1002/cne.10525. PMID 12509874.
• Zheng S, Yu P, Zeng C, et al. (2003). "Galpha12- and Galpha13-protein subunit linkage of D5 dopamine receptors in the nephron.". Hypertension 41 (3): 604-10. doi:10.1161/01.HYP.0000057422.75590.D7. PMID 12623966.

External links

• MeSH DRD5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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