Bombesin-like receptor 3

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Bombesin-like receptor 3
Identifiers
Symbol(s) BRS3;
External IDs OMIM: 300107 MGI: 1100501 Homologene: 1307
RNA expression pattern

Image:PBB GE BRS3 207369 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 680 12209
Ensembl ENSG00000102239 ENSMUSG00000031130
Uniprot P32247 O54798
Refseq NM_001727 (mRNA)
NP_001718 (protein) 		NM_009766 (mRNA)
NP_033896 (protein)
Location Chr X: 135.4 - 135.4 Mb Chr X: 53.39 - 53.4 Mb
Pubmed search [1] [2]

The bombesin-like receptor 3 (BRS-3) is a G protein-coupled receptor.[1] As no endogenous ligand has been identified for BRS-3, it is classified as an orphan receptor.


Mammalian bombesin-like peptides (see MIM 137260) are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor (MIM 305670), neuromedin B receptor (MIM 162341), and bombesin-like receptor-3 (BRS3) (Ohki-Hamazaki et al., 1997).[supplied by OMIM][1]


References

Further reading

  • Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.". FEBS Lett. 340 (3): 260-4. PMID 8131855.
  • Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.". J. Biol. Chem. 268 (8): 5979-84. PMID 8383682.
  • Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111-8. PMID 8822519.
  • Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity.". Nature 390 (6656): 165-9. doi:10.1038/36568. PMID 9367152.
  • Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.". J. Biol. Chem. 273 (22): 13613-24. PMID 9593699.
  • Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3).". Biochemistry 41 (28): 8954-60. PMID 12102638.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
  • Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells.". Lung Cancer 54 (2): 143-8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.
  • Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells.". Biochem. J. 405 (1): 131-7. doi:10.1042/BJ20061754. PMID 17355223.

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin likeAcetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin likeBrain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromoneCalcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / SmoothenedFrizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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