EMR1

Egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
Symbol(s)	EMR1; TM7LN3
External IDs	OMIM: 600493 MGI: 106912 Homologene: 1493
Gene ontology Molecular Function: • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular Component: • integral to plasma membrane • membrane • integral to membrane Biological Process: • cell adhesion • signal transduction • neuropeptide signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2015	13733
Ensembl	ENSG00000174837	ENSMUSG00000004730
Uniprot	Q14246	Q3S4B0
Refseq	NM_001974 (mRNA) NP_001965 (protein)	NM_010130 (mRNA) NP_034260 (protein)
Location	Chr 19: 6.84 - 6.89 Mb	Chr 17: 57.04 - 57.17 Mb
Pubmed search	[1]	[2]

Egf-like module containing, mucin-like, hormone receptor-like 1, also known as EMR1, is a human gene.

This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties.

See also

• EGF module-containing mucin-like hormone receptor

Further reading

• McKnight AJ, Gordon S (1998). "The EGF-TM7 family: unusual structures at the leukocyte surface.". J. Leukoc. Biol. 63 (3): 271-80. PMID 9500513.
• Baud V, Chissoe SL, Viegas-Péquignot E, et al. (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments.". Genomics 26 (2): 334-44. PMID 7601460.
• McKnight AJ, Macfarlane AJ, Seldin MF, Gordon S (1998). "Chromosome mapping of the Emr1 gene.". Mamm. Genome 8 (12): 946. PMID 9383301.
• Carver EA, Hamann J, Olsen AS, Stubbs L (2000). "Physical mapping of EMR1 and CD97 in human Chromosome 19 and assignment of Cd97 to mouse Chromosome 8 suggest an ancient genomic duplication.". Mamm. Genome 10 (10): 1039-40. PMID 10501980.
• Lin HH, Stacey M, Hamann J, et al. (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.". Genomics 67 (2): 188-200. doi:10.1006/geno.2000.6238. PMID 10903844.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.