ALCAM

Activated leukocyte cell adhesion molecule
Identifiers
Symbol(s)	ALCAM; CD166; FLJ38514; MEMD; MGC71733
External IDs	OMIM: 601662 MGI: 1313266 Homologene: 1229
Gene ontology Molecular Function: • receptor binding Cellular Component: • membrane fraction • integral to plasma membrane • membrane Biological Process: • cell adhesion • signal transduction • antimicrobial humoral response
Orthologs
	Human	Mouse
Entrez	214	11658
Ensembl	ENSG00000170017	ENSMUSG00000022636
Uniprot	Q13740	Q3TTY3
Refseq	NM_001627 (mRNA) NP_001618 (protein)	NM_009655 (mRNA) NP_033785 (protein)
Location	Chr 3: 106.57 - 106.78 Mb	Chr 16: 52.17 - 52.37 Mb
Pubmed search	[1]	[2]

Activated leukocyte cell adhesion molecule, also known as ALCAM, is a human gene.. It is also called CD166 (cluster of differentiation 166).

Further reading

• Whitney GS, Starling GC, Bowen MA, et al. (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site.". J. Biol. Chem. 270 (31): 18187-90. PMID 7543097.
• Bowen MA, Patel DD, Li X, et al. (1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand.". J. Exp. Med. 181 (6): 2213-20. PMID 7760007.
• Bajorath J, Bowen MA, Aruffo A (1996). "Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM.". Protein Sci. 4 (8): 1644-7. PMID 8520490.
• Skonier JE, Bowen MA, Emswiler J, et al. (1996). "Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM.". Biochemistry 35 (38): 12287-91. doi:10.1021/bi961038k. PMID 8823162.
• Singer NG, Mitra R, Lialios F, et al. (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes.". Immunol. Lett. 58 (1): 9-14. PMID 9436462.
• Degen WG, van Kempen LC, Gijzen EG, et al. (1998). "MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule).". Am. J. Pathol. 152 (3): 805-13. PMID 9502422.
• Cortés F, Deschaseaux F, Uchida N, et al. (1999). "HCA, an immunoglobulin-like adhesion molecule present on the earliest human hematopoietic precursor cells, is also expressed by stromal cells in blood-forming tissues.". Blood 93 (3): 826-37. PMID 9920831.
• Tomita K, van Bokhoven A, Jansen CF, et al. (2000). "Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin.". Biochem. Biophys. Res. Commun. 267 (3): 870-4. doi:10.1006/bbrc.1999.2040. PMID 10673383.
• van Kempen LC, Nelissen JM, Degen WG, et al. (2001). "Molecular basis for the homophilic activated leukocyte cell adhesion molecule (ALCAM)-ALCAM interaction.". J. Biol. Chem. 276 (28): 25783-90. doi:10.1074/jbc.M011272200. PMID 11306570.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Kristiansen G, Pilarsky C, Wissmann C, et al. (2003). "ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions.". Prostate 54 (1): 34-43. doi:10.1002/pros.10161. PMID 12481253.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660-6. doi:10.1038/nbt827. PMID 12754519.
• Fujiwara H, Tatsumi K, Kosaka K, et al. (2003). "Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166).". J. Clin. Endocrinol. Metab. 88 (7): 3437-43. PMID 12843199.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• van Kempen LC, Meier F, Egeblad M, et al. (2004). "Truncation of activated leukocyte cell adhesion molecule: a gateway to melanoma metastasis.". J. Invest. Dermatol. 122 (5): 1293-301. doi:10.1111/j.0022-202X.2004.22531.x. PMID 15140234.
• Zimmerman AW, Nelissen JM, van Emst-de Vries SE, et al. (2005). "Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.". J. Cell. Sci. 117 (Pt 13): 2841-52. doi:10.1242/jcs.01139. PMID 15169840.
• Ikeda K, Quertermous T (2005). "Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function.". J. Biol. Chem. 279 (53): 55315-23. doi:10.1074/jbc.M407776200. PMID 15496415.
• Verma A, Shukla NK, Deo SV, et al. (2005). "MEMD/ALCAM: a potential marker for tumor invasion and nodal metastasis in esophageal squamous cell carcinoma.". Oncology 68 (4-6): 462-70. doi:10.1159/000086989. PMID 16024937.
• Lunter PC, van Kilsdonk JW, van Beek H, et al. (2005). "Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity.". Cancer Res. 65 (19): 8801-8. doi:10.1158/0008-5472.CAN-05-0378. PMID 16204050.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070-80. doi:10.1021/pr0502065. PMID 16335952.