GPR37

G protein-coupled receptor 37 (endothelin receptor type B-like)
Identifiers
Symbol(s)	GPR37; EDNRBL; PAELR; hET(B)R-LP
External IDs	OMIM: 602583 MGI: 1313297 Homologene: 3875
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2861	14763
Ensembl	ENSG00000170775	ENSMUSG00000039904
Uniprot	O15354	Q9QY42
Refseq	NM_005302 (mRNA) NP_005293 (protein)	NM_010338 (mRNA) NP_034468 (protein)
Location	Chr 7: 124.17 - 124.19 Mb	Chr 6: 25.62 - 25.64 Mb
Pubmed search	[1]	[2]

G protein-coupled receptor 37 (endothelin receptor type B-like), also known as GPR37, is a human gene.

Further reading

• Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain.". Biochem. Biophys. Res. Commun. 233 (2): 559-67. doi:10.1006/bbrc.1997.6408. PMID 9144577.
• Marazziti D, Golini E, Gallo A, et al. (1997). "Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library.". Genomics 45 (1): 68-77. doi:10.1006/geno.1997.4900. PMID 9339362.
• Donohue PJ, Shapira H, Mantey SA, et al. (1998). "A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.". Brain Res. Mol. Brain Res. 54 (1): 152-60. PMID 9526070.
• Imai Y, Soda M, Inoue H, et al. (2001). "An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.". Cell 105 (7): 891-902. PMID 11439185.
• Imai Y, Soda M, Hatakeyama S, et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.". Mol. Cell 10 (1): 55-67. PMID 12150907.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Yang Y, Nishimura I, Imai Y, et al. (2003). "Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.". Neuron 37 (6): 911-24. PMID 12670421.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767-72. doi:10.1126/science.1083423. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948.
• Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.". J. Biol. Chem. 278 (51): 51901-10. doi:10.1074/jbc.M309655200. PMID 14532270.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Kubota K, Niinuma Y, Kaneko M, et al. (2006). "Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.". J. Neurochem. 97 (5): 1259-68. doi:10.1111/j.1471-4159.2006.03782.x. PMID 16539653.
• Omura T, Kaneko M, Okuma Y, et al. (2007). "A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.". J. Neurochem. 99 (6): 1456-69. doi:10.1111/j.1471-4159.2006.04155.x. PMID 17059562.