Somatostatin receptor 5

Somatostatin receptor 5
Identifiers
Symbol(s)	SSTR5;
External IDs	OMIM: 182455 MGI: 894282 Homologene: 20287
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • somatostatin receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • negative regulation of cell proliferation • glucose homeostasis • regulation of insulin secretion
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6755	20609
Ensembl	ENSG00000162009	ENSMUSG00000050824
Uniprot	P35346	O35715
Refseq	NM_001053 (mRNA) NP_001044 (protein)	NM_011425 (mRNA) NP_035555 (protein)
Location	Chr 16: 1.07 - 1.07 Mb	Chr 17: 25.22 - 25.22 Mb
Pubmed search	[1]	[2]

Somatostatin receptor 5, also known as SSTR5, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments.

See also

• Somatostatin receptor

Further reading

• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251-5. PMID 1346068.
• Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin.". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337-40. PMID 6145156.
• Takeda J, Fernald AA, Yamagata K, et al. (1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization.". Genomics 26 (3): 638-9. PMID 7607700.
• Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28.". Mol. Pharmacol. 45 (3): 417-27. PMID 7908405.
• O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5.". Mol. Pharmacol. 46 (2): 291-8. PMID 8078491.
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.". Biochem. Biophys. Res. Commun. 195 (2): 844-52. PMID 8373420.
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449-52. doi:10.1006/geno.1993.1088. PMID 8449518.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157-63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines.". J. Clin. Endocrinol. Metab. 82 (6): 1857-62. PMID 9177396.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499-506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639-44. PMID 9279525.
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization.". J. Biol. Chem. 273 (33): 21416-22. PMID 9694905.
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82-90. PMID 9892014.
• Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.". Diabetes 48 (1): 77-85. PMID 9892225.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers.". J. Biol. Chem. 275 (11): 7862-9. PMID 10713101.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity.". Science 288 (5463): 154-7. PMID 10753124.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339-52. PMID 11157797.
• Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment.". J. Clin. Endocrinol. Metab. 86 (8): 3809-14. PMID 11502816.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175-9. PMID 11753241.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461-75. doi:10.1007/s00428-002-0609-x. PMID 12021920.

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• MeSH somatostatin+receptor+5

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.