EMR3

Egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
Symbol(s)	EMR3;
External IDs	OMIM: 606101 Homologene: 50009
Gene ontology Molecular Function: • receptor activity • G-protein coupled receptor activity • calcium ion binding Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • neuropeptide signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	84658	na
Ensembl	ENSG00000131355	na
Uniprot	Q9BY15	na
Refseq	NM_032571 (mRNA) NP_115960 (protein)	na (mRNA) na (protein)
Location	Chr 19: 14.57 - 14.65 Mb	na
Pubmed search	[1]	na

Egf-like module containing, mucin-like, hormone receptor-like 3, also known as EMR3, is a human gene.

This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses.

See also

• EGF module-containing mucin-like hormone receptor

Further reading

• Stacey M, Lin HH, Hilyard KL, et al. (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils.". J. Biol. Chem. 276 (22): 18863-70. doi:10.1074/jbc.M101147200. PMID 11279179.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23-33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Matmati M, Pouwels W, van Bruggen R, et al. (2007). "The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.". J. Leukoc. Biol. 81 (2): 440-8. doi:10.1189/jlb.0406276. PMID 17108056.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.