GPR132

G protein-coupled receptor 132
Identifiers
Symbol(s)	GPR132; G2A; MGC99642
External IDs	OMIM: 606167 MGI: 1890220 Homologene: 8350
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • G1/S transition of mitotic cell cycle • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	29933	56696
Ensembl	ENSG00000183484	ENSMUSG00000021298
Uniprot	Q9UNW8	Q0VBS4
Refseq	NM_013345 (mRNA) NP_037477 (protein)	NM_019925 (mRNA) NP_064309 (protein)
Location	Chr 14: 104.59 - 104.6 Mb	Chr 12: 113.3 - 113.31 Mb
Pubmed search	[1]	[2]

G protein-coupled receptor 132, also known as GPR132, is a human gene.

This gene encodes a subfamily member of the G-protein couple receptor (GPCR) superfamily. The encoded protein is a high-affinity receptor for lysophosphatidylcholine (LPC), a major phospholipid component of oxidized low density lipoprotein. This protein may react to LPC levels at sites of inflammation to limit the expansion of tissue-infiltrating cells. A similar protein in mouse is involved in cell cycle progression.

Further reading

• Weng Z, Fluckiger AC, Nisitani S, et al. (1998). "A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M.". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12334-9. PMID 9770487.
• Kabarowski JH, Zhu K, Le LQ, et al. (2001). "Lysophosphatidylcholine as a ligand for the immunoregulatory receptor G2A.". Science 293 (5530): 702-5. doi:10.1126/science.1061781. PMID 11474113.
• Le LQ, Kabarowski JH, Wong S, et al. (2002). "Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene.". Cancer Cell 1 (4): 381-91. PMID 12086852.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Rikitake Y, Hirata K, Yamashita T, et al. (2002). "Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques.". Arterioscler. Thromb. Vasc. Biol. 22 (12): 2049-53. PMID 12482833.
• Lin P, Ye RD (2003). "The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis.". J. Biol. Chem. 278 (16): 14379-86. doi:10.1074/jbc.M209101200. PMID 12586833.
• Lum H, Qiao J, Walter RJ, et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786-9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.
• Murakami N, Yokomizo T, Okuno T, Shimizu T (2004). "G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine.". J. Biol. Chem. 279 (41): 42484-91. doi:10.1074/jbc.M406561200. PMID 15280385.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Witte ON, Kabarowski JH, Xu Y, et al. (2005). "Retraction.". Science 307 (5707): 206. doi:10.1126/science.307.5707.206b. PMID 15653487.
• Radu CG, Nijagal A, McLaughlin J, et al. (2005). "Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.". Proc. Natl. Acad. Sci. U.S.A. 102 (5): 1632-7. doi:10.1073/pnas.0409415102. PMID 15665078.
• Obinata H, Hattori T, Nakane S, et al. (2006). "Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A.". J. Biol. Chem. 280 (49): 40676-83. doi:10.1074/jbc.M507787200. PMID 16236715.
• Frasch SC, Zemski-Berry K, Murphy RC, et al. (2007). "Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A.". J. Immunol. 178 (10): 6540-8. PMID 17475884.

{Template:Membrane-protein-stub