TAS2R1

Taste receptor, type 2, member 1
Identifiers
Symbol(s)	TAS2R1; MGC126778; MGC126780; T2R1; TRB7
External IDs	OMIM: 604796 MGI: 2681253 Homologene: 10480
Gene ontology Molecular Function: • receptor activity • G-protein coupled receptor activity • taste receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • chemosensory behavior • response to stimulus • sensory perception of taste
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	50834	57254
Ensembl	ENSG00000169777	ENSMUSG00000045267
Uniprot	Q9NYW7	Q9JKT2
Refseq	NM_019599 (mRNA) NP_062545 (protein)	NM_020503 (mRNA) NP_065249 (protein)
Location	Chr 5: 9.68 - 9.68 Mb	Chr 15: 32.12 - 32.12 Mb
Pubmed search	[1]	[2]

Taste receptor, type 2, member 1, also known as TAS2R1, is a human gene.

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507-10. PMID 10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1-4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366-71. PMID 12139982.
• Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693-702. PMID 10761934.
• Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703-11. PMID 10761935.
• Firestein S (2000). "The good taste of genomics.". Nature 404 (6778): 552-3. doi:10.1038/35007167. PMID 10766221.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601-4. doi:10.1038/35007072. PMID 10766242.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293-301. PMID 12581520.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432-6. doi:10.1093/molbev/msi027. PMID 15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313-26. doi:10.1534/genetics.104.037523. PMID 15744053.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.