Melanocortin 4 receptor

Melanocortin 4 receptor
Identifiers
Symbol(s)	MC4R; MGC126851; MGC138197
External IDs	OMIM: 155541 MGI: 99457 Homologene: 4320
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • melanocortin receptor activity • protein binding Cellular Component: • plasma membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, coupled to cAMP nucleotide second messenger • feeding behavior • regulation of metabolic process • positive regulation of bone resorption
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	4160	17202
Ensembl	ENSG00000166603	ENSMUSG00000047259
Uniprot	P32245	Q49NR1
Refseq	NM_005912 (mRNA) NP_005903 (protein)	NM_016977 (mRNA) NP_058673 (protein)
Location	Chr 18: 56.19 - 56.19 Mb	Chr 18: 66.98 - 66.99 Mb
Pubmed search	[1]	[2]

Melanocortin 4 receptor, also known as MC4R, is a human gene.

See also

• Melanocortin receptor

Further reading

• Mountjoy KG, Mortrud MT, Low MJ, et al. (1995). "Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.". Mol. Endocrinol. 8 (10): 1298-308. PMID 7854347.
• Magenis RE, Smith L, Nadeau JH, et al. (1994). "Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human.". Mamm. Genome 5 (8): 503-8. PMID 7949735.
• Gantz I, Miwa H, Konda Y, et al. (1993). "Molecular cloning, expression, and gene localization of a fourth melanocortin receptor.". J. Biol. Chem. 268 (20): 15174-9. PMID 8392067.
• Alvaro JD, Tatro JB, Quillan JM, et al. (1996). "Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction.". Mol. Pharmacol. 50 (3): 583-91. PMID 8794897.
• Yang YK, Ollmann MM, Wilson BD, et al. (1997). "Effects of recombinant agouti-signaling protein on melanocortin action.". Mol. Endocrinol. 11 (3): 274-80. PMID 9058374.
• Chagnon YC, Chen WJ, Pérusse L, et al. (1998). "Linkage and association studies between the melanocortin receptors 4 and 5 genes and obesity-related phenotypes in the Québec Family Study.". Mol. Med. 3 (10): 663-73. PMID 9392003.
• Sundaramurthy D, Campbell DA, Leek JP, et al. (1998). "Assignment of the melanocortin 4 receptor (MC4R) gene to human chromosome band 18q22 by in situ hybridisation and radiation hybrid mapping.". Cytogenet. Cell Genet. 82 (1-2): 97-8. PMID 9763669.
• Yeo GS, Farooqi IS, Aminian S, et al. (1998). "A frameshift mutation in MC4R associated with dominantly inherited human obesity.". Nat. Genet. 20 (2): 111-2. doi:10.1038/2404. PMID 9771698.
• Vaisse C, Clement K, Guy-Grand B, Froguel P (1998). "A frameshift mutation in human MC4R is associated with a dominant form of obesity.". Nat. Genet. 20 (2): 113-4. doi:10.1038/2407. PMID 9771699.
• Hinney A, Schmidt A, Nottebom K, et al. (1999). "Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans.". J. Clin. Endocrinol. Metab. 84 (4): 1483-6. PMID 10199800.
• Yang YK, Dickinson CJ, Zeng Q, et al. (1999). "Contribution of melanocortin receptor exoloops to Agouti-related protein binding.". J. Biol. Chem. 274 (20): 14100-6. PMID 10318826.
• Ho G, MacKenzie RG (2000). "Functional characterization of mutations in melanocortin-4 receptor associated with human obesity.". J. Biol. Chem. 274 (50): 35816-22. PMID 10585465.
• Yang YK, Fong TM, Dickinson CJ, et al. (2001). "Molecular determinants of ligand binding to the human melanocortin-4 receptor.". Biochemistry 39 (48): 14900-11. PMID 11101306.
• Mergen M, Mergen H, Ozata M, et al. (2001). "A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity.". J. Clin. Endocrinol. Metab. 86 (7): 3448. PMID 11443223.
• McNulty JC, Thompson DA, Bolin KA, et al. (2002). "High-resolution NMR structure of the chemically-synthesized melanocortin receptor binding domain AGRP(87-132) of the agouti-related protein.". Biochemistry 40 (51): 15520-7. PMID 11747427.
• Brocke KS, Neu-Yilik G, Gehring NH, et al. (2002). "The human intronless melanocortin 4-receptor gene is NMD insensitive.". Hum. Mol. Genet. 11 (3): 331-5. PMID 11823452.
• Yang Y, Chen M, Lai Y, et al. (2002). "Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity.". J. Biol. Chem. 277 (23): 20328-35. doi:10.1074/jbc.M201343200. PMID 11912210.
• Hansen MJ, Morris MJ (2002). "Evidence for an interaction between neuropeptide Y and the melanocortin-4 receptor on feeding in the rat.". Neuropharmacology 42 (6): 792-7. PMID 12015205.
• Miraglia Del Giudice E, Cirillo G, Nigro V, et al. (2002). "Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity.". Int. J. Obes. Relat. Metab. Disord. 26 (5): 647-51. doi:10.1038/sj.ijo.0801983. PMID 12032748.
• Kim CS, Lee SH, Kim RY, et al. (2002). "Identification of domains directing specificity of coupling to G-proteins for the melanocortin MC3 and MC4 receptors.". J. Biol. Chem. 277 (35): 31310-7. doi:10.1074/jbc.M112085200. PMID 12045190.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub