Prostaglandin E2 receptor

You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.

Jump to: navigation, search


Prostaglandin E receptor 2 (subtype EP2), 53kDa
Identifiers
Symbol(s) PTGER2; EP2
External IDs OMIM: 176804 MGI: 97794 Homologene: 739
RNA expression pattern

Image:PBB GE PTGER2 206631 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 5732 19217
Ensembl ENSG00000125384 ENSMUSG00000037759
Uniprot P43116 Q3UW60
Refseq NM_000956 (mRNA)
NP_000947 (protein) 		NM_008964 (mRNA)
NP_032990 (protein)
Location Chr 14: 51.85 - 51.87 Mb Chr 14: 43.91 - 43.93 Mb
Pubmed search [1] [2]

Prostaglandin E2 receptor (53kDa), also known as PTGER2, subtype EP2 or Prostaglandin E receptor 2, is a prostaglandin receptor for prostaglandin E2. It also denotes the human gene encoding the receptor.[1]

Contents

Mechanism

The receptor is a G-protein coupled receptor, which activates the G protein Gs.[1].



See also

References

Further reading

  • Duncan AM, Anderson LL, Funk CD, et al. (1995). "Chromosomal localization of the human prostanoid receptor gene family.". Genomics 25 (3): 740-2. PMID 7759114.
  • Regan JW, Bailey TJ, Pepperl DJ, et al. (1994). "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype.". Mol. Pharmacol. 46 (2): 213-20. PMID 8078484.
  • Bastien L, Sawyer N, Grygorczyk R, et al. (1994). "Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.". J. Biol. Chem. 269 (16): 11873-7. PMID 8163486.
  • An S, Yang J, Xia M, Goetzl EJ (1994). "Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.". Biochem. Biophys. Res. Commun. 197 (1): 263-70. PMID 8250933.
  • Stillman BA, Breyer MD, Breyer RM (1999). "Importance of the extracellular domain for prostaglandin EP(2) receptor function.". Mol. Pharmacol. 56 (3): 545-51. PMID 10462542.
  • Smock SL, Pan LC, Castleberry TA, et al. (1999). "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E(2) receptor EP2 subtype.". Gene 237 (2): 393-402. PMID 10521663.
  • Desai S, April H, Nwaneshiudu C, Ashby B (2001). "Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.". Mol. Pharmacol. 58 (6): 1279-86. PMID 11093764.
  • Duckworth N, Marshall K, Clayton JK (2002). "An investigation of the effect of the prostaglandin EP2 receptor agonist, butaprost, on the human isolated myometrium from pregnant and non-pregnant women.". J. Endocrinol. 172 (2): 263-9. PMID 11834444.
  • Kyveris A, Maruscak E, Senchyna M (2002). "Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR.". Mol. Vis. 8: 51-8. PMID 11951086.
  • Takafuji VA, Evans A, Lynch KR, Roche JK (2003). "PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer.". Prostaglandins Leukot. Essent. Fatty Acids 66 (1): 71-81. doi:10.1054/plef.2001.0299. PMID 12051958.
  • Scandella E, Men Y, Gillessen S, et al. (2002). "Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells.". Blood 100 (4): 1354-61. doi:10.1182/blood-2001-11-0017. PMID 12149218.
  • Okuyama T, Ishihara S, Sato H, et al. (2002). "Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines.". J. Lab. Clin. Med. 140 (2): 92-102. PMID 12228765.
  • Konger RL, Scott GA, Landt Y, et al. (2003). "Loss of the EP2 prostaglandin E2 receptor in immortalized human keratinocytes results in increased invasiveness and decreased paxillin expression.". Am. J. Pathol. 161 (6): 2065-78. PMID 12466123.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Abulencia JP, Gaspard R, Healy ZR, et al. (2003). "Shear-induced cyclooxygenase-2 via a JNK2/c-Jun-dependent pathway regulates prostaglandin receptor expression in chondrocytic cells.". J. Biol. Chem. 278 (31): 28388-94. doi:10.1074/jbc.M301378200. PMID 12743126.
  • Richards JA, Brueggemeier RW (2003). "Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes.". J. Clin. Endocrinol. Metab. 88 (6): 2810-6. PMID 12788892.
  • Sun HS, Hsiao KY, Hsu CC, et al. (2003). "Transactivation of steroidogenic acute regulatory protein in human endometriotic stromalcells is mediated by the prostaglandin EP2 receptor.". Endocrinology 144 (9): 3934-42. PMID 12933667.
  • Bradbury DA, Newton R, Zhu YM, et al. (2004). "Cyclooxygenase-2 induction by bradykinin in human pulmonary artery smooth muscle cells is mediated by the cyclic AMP response element through a novel autocrine loop involving endogenous prostaglandin E2, E-prostanoid 2 (EP2), and EP4 receptors.". J. Biol. Chem. 278 (50): 49954-64. doi:10.1074/jbc.M307964200. PMID 14517215.
  • Moreland RB, Kim N, Nehra A, et al. (2004). "Functional prostaglandin E (EP) receptors in human penile corpus cavernosum.". Int. J. Impot. Res. 15 (5): 362-8. doi:10.1038/sj.ijir.3901042. PMID 14562138.
  • Sugimoto Y, Nakato T, Kita A, et al. (2004). "A cluster of aromatic amino acids in the i2 loop plays a key role for Gs coupling in prostaglandin EP2 and EP3 receptors.". J. Biol. Chem. 279 (12): 11016-26. doi:10.1074/jbc.M307404200. PMID 14699136.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin likeAcetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin likeBrain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromoneCalcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / SmoothenedFrizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

Retrieved from "http://www.wikidoc.org/index.php/Prostaglandin_E2_receptor"
Personal tools