CD61

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
PDB rendering based on 1jv2.
Available structures: 1jv2, 1l5g, 1m1x, 1m8o, 1txv, 1ty3, 1ty5, 1ty6, 1ty7, 1tye, 1u8c
Identifiers
Symbol(s)	ITGB3; CD61; GP3A; GPIIIa
External IDs	OMIM: 173470 MGI: 96612 Homologene: 55444
Gene ontology Molecular Function: • receptor activity • integrin binding • identical protein binding Cellular Component: • integrin complex • external side of plasma membrane • membrane Biological Process: • cell-substrate junction assembly • cell adhesion • cell-matrix adhesion • integrin-mediated signaling pathway • multicellular organismal development • blood coagulation • regulation of cell migration
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	3690	16416
Ensembl	ENSG00000056345	ENSMUSG00000020689
Uniprot	P05106	P97483
Refseq	NM_000212 (mRNA) NP_000203 (protein)	NM_016780 (mRNA) NP_058060 (protein)
Location	Chr 17: 42.69 - 42.75 Mb	Chr 11: 104.42 - 104.48 Mb
Pubmed search	[1]	[2]

Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61), also known as ITGB3, is a human gene. CD61 is a cluster of differentiation found on thrombocytes.

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

See also

• Glycoprotein IIb/IIIa

Further reading

• Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization.". Thromb. Haemost. 72 (4): 492-502. PMID 7878622.
• Bennett JS (2001). "Platelet-fibrinogen interactions.". Ann. N. Y. Acad. Sci. 936: 340-54. PMID 11460491.
• Sajid M, Stouffer GA (2002). "The role of alpha(v)beta3 integrins in vascular healing.". Thromb. Haemost. 87 (2): 187-93. PMID 11858476.
• Quinn MJ, Byzova TV, Qin J, et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. doi:10.1161/01.ATV.0000066686.46338.F1. PMID 12637342.
• Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in cardiovascular thrombotic disease.". Italian heart journal : official journal of the Italian Federation of Cardiology 4 (1): 17-22. PMID 12690916.
• Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and fibrinogen T/G+1689 polymorphisms with peripheral arterial disease and ischaemic heart disease.". Thromb. Res. 112 (4): 209-16. doi:10.1016/j.thromres.2003.11.010. PMID 14987913.
• Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis.". Curr. Pharm. Des. 10 (14): 1567-76. PMID 15134555.
• Cacciari B, Spalluto G (2005). "Non peptidic alphavbeta3 antagonists: recent developments.". Curr. Med. Chem. 12 (1): 51-70. PMID 15638730.
• Watson SP, Auger JM, McCarty OJ, Pearce AC (2005). "GPVI and integrin alphaIIb beta3 signaling in platelets.". J. Thromb. Haemost. 3 (8): 1752-62. doi:10.1111/j.1538-7836.2005.01429.x. PMID 16102042.
• Bennett JS (2006). "Structure and function of the platelet integrin alphaIIbbeta3.". J. Clin. Invest. 115 (12): 3363-9. doi:10.1172/JCI26989. PMID 16322781.

External links

• MeSH CD61+Antigens