Formyl peptide receptor
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| Identifiers | |
| Symbol | FPR1 |
| Entrez | 2357 |
| HUGO | 3826 |
| OMIM | 136537 |
| RefSeq | NM_002029 |
| UniProt | P21462 |
| Other data | |
| Locus | Chr. 19 q13.41 |
| Identifiers | |
| Symbol | FPRL1 |
| Entrez | 2358 |
| HUGO | 3827 |
| OMIM | 136538 |
| RefSeq | NM_001462 |
| UniProt | P25090 |
| Other data | |
| Locus | Chr. 19 q13.3-13.4 |
| Identifiers | |
| Symbol | FPRL2 |
| Entrez | 2359 |
| HUGO | 3828 |
| OMIM | 136539 |
| RefSeq | NM_002030 |
| UniProt | P25089 |
| Other data | |
| Locus | Chr. 19 q13.3-13.4 |
The formyl peptide receptors are a members of a class of G protein-coupled receptors involved in chemotaxis.[1] These receptors where originally identified by their ability to bind N-formyl peptides such as N-formylmethionine produced by the degradation of either bacterial or host cells.[2][3] Hence formyl peptide receptors are involved in mediating immune cell response to infection. These receptors may also act to suppress the immune system under certain conditions.[4]
References
- ↑ Migeotte I, Communi D, Parmentier M (2006). "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses". Cytokine Growth Factor Rev. 17 (6): 501–19. doi:10.1016/j.cytogfr.2006.09.009. PMID 17084101.
- ↑ Le Y, Murphy PM, Wang JM (2002). "Formyl-peptide receptors revisited". Trends Immunol. 23 (11): 541–8. doi:10.1016/S1471-4906(02)02316-5. PMID 12401407.
- ↑ Panaro MA, Acquafredda A, Sisto M, Lisi S, Maffione AB, Mitolo V (2006). "Biological role of the N-formyl peptide receptors". Immunopharmacology and immunotoxicology 28 (1): 103–27. doi:10.1080/08923970600625975. PMID 16684671.
- ↑ Braun MC, Wang JM, Lahey E, Rabin RL, Kelsall BL (2001). "Activation of the formyl peptide receptor by the HIV-derived peptide T-20 suppresses interleukin-12 p70 production by human monocytes". Blood 97 (11): 3531–6. doi:10.1182/blood.V97.11.3531. PMID 11369647.
See also
External links
Transmembrane receptors: immune receptors | |
|---|---|
| Cytokine receptor | Type I: interleukin (IL-2, IL-3) - CSF (Erythropoietin, GM-CSF, G-CSF) - Glycoprotein 130/Oncostatin M - Leukemia inhibitory factor - common subunits (Common gamma chain, CSF2RB) Type II: interleukin (IL22RA2) - interferon (IFNAR, IFNGR) |
| Pattern recognition/Toll-like | TLR 1 - TLR 2 - TLR 3 - TLR 4 - TLR 5 - TLR 6 - TLR 7 - TLR 8 - TLR 9 - TLR 10 |
| Fc receptor | ε (FcεRI, FcεRII) - γ (FcγRI, FcγRII, FcγRIII) - α/μ (FcαRI, Fcα/μR) - Neonatal |
| Lymphocyte homing receptor | CD44 - L-selectin - VLA-4 - LFA-1 |
| other | Antigen receptor (B-cell, T cell) - Complement - Formyl peptide - Immunophilins - Integrin - Killer-cell immunoglobulin-like - Scavenger |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
