P2RY8

Purinergic receptor P2Y, G-protein coupled, 8
Identifiers
Symbol(s)	P2RY8; MGC50878; P2Y8
External IDs	OMIM: 300525 Homologene: 65345
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	286530	na
Ensembl	ENSG00000182162	na
Uniprot	Q86VZ1	na
Refseq	NM_178129 (mRNA) NP_835230 (protein)	na (mRNA) na (protein)
Location	Chr X: 1.54 - 1.62 Mb	na
Pubmed search	[1]	na

Purinergic receptor P2Y, G-protein coupled, 8, also known as P2RY8, is a human gene.

The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.

See also

• P2Y receptor

Further reading

• Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells.". Biochim. Biophys. Acta 1492 (1): 127-38. PMID 11004484.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Cantagrel V, Lossi AM, Boulanger S, et al. (2005). "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males.". J. Med. Genet. 41 (10): 736-42. doi:10.1136/jmg.2004.021626. PMID 15466006.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
• Fujiwara S, Yamashita Y, Choi YL, et al. (2007). "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening.". Leuk. Lymphoma 48 (5): 978-86. doi:10.1080/10428190701225882. PMID 17487742.
• Storlazzi CT, Albano F, Lo Cunsolo C, et al. (2007). "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma.". Leukemia 21 (10): 2221-5. doi:10.1038/sj.leu.2404784. PMID 17554380.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.