TAS2R8

Taste receptor, type 2, member 8
Identifiers
Symbol(s)	TAS2R8; T2R8; TRB5
External IDs	OMIM: 604794 Homologene: 88894
Gene ontology Molecular Function: • receptor activity • taste receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • response to stimulus • sensory perception of taste
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	50836	na
Ensembl	ENSG00000121314	na
Uniprot	Q9NYW2	na
Refseq	NM_023918 (mRNA) NP_076407 (protein)	na (mRNA) na (protein)
Location	Chr 12: 10.85 - 10.85 Mb	na
Pubmed search	[1]	na

Taste receptor, type 2, member 8, also known as TAS2R8, is a human gene.

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.

See also

• Taste receptor

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors.". Neuron 25 (3): 507-10. PMID 10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction.". J. Biol. Chem. 277 (1): 1-4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste.". Curr. Opin. Neurobiol. 12 (4): 366-71. PMID 12139982.
• Adler E, Hoon MA, Mueller KL, et al. (2000). "A novel family of mammalian taste receptors.". Cell 100 (6): 693-702. PMID 10761934.
• Chandrashekar J, Mueller KL, Hoon MA, et al. (2000). "T2Rs function as bitter taste receptors.". Cell 100 (6): 703-11. PMID 10761935.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse.". Nature 404 (6778): 601-4. doi:10.1038/35007072. PMID 10766242.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Zhang Y, Hoon MA, Chandrashekar J, et al. (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.". Cell 112 (3): 293-301. PMID 12581520.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes.". Mol. Biol. Evol. 22 (3): 432-6. doi:10.1093/molbev/msi027. PMID 15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.". Genetics 170 (1): 313-26. doi:10.1534/genetics.104.037523. PMID 15744053.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.