F2RL3

	Coagulation factor II (thrombin) receptor-like 3
	Identifiers
Symbol(s)	F2RL3; PAR4
External IDs	OMIM: 602779 MGI: 1298207 Homologene: 36148
Gene ontology
Molecular Function:	• rhodopsin-like receptor activity; • receptor activity; • thrombin receptor activity;
Cellular Component:	• plasma membrane; • integral to plasma membrane;
Biological Process:	• signal transduction; • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); • blood coagulation; • response to wounding;
	RNA expression pattern
	More reference expression data
	Orthologs

Coagulation factor II (thrombin) receptor-like 3, also known as F2RL3 or protease activated receptor 4 (PAR4), is a human gene.^[1]

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.^[1]

References

↑ ^1.0 ^1.1 Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3.

Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases.". Circulation 114 (10): 1070-7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995.
Xu WF, Andersen H, Whitmore TE, et al. (1998). "Cloning and characterization of human protease-activated receptor 4.". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642-6. PMID 9618465.
Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation.". Nature 394 (6694): 690-4. doi:10.1038/29325. PMID 9716134.
Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family.". J. Biol. Chem. 273 (36): 23290-6. PMID 9722561.
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.". J. Clin. Invest. 103 (6): 879-87. PMID 10079109.
Andersen H, Greenberg DL, Fujikawa K, et al. (1999). "Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity.". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189-93. PMID 10500152.
Page G, Kögel D, Rangnekar V, Scheidtmann KH (2000). "Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis.". Oncogene 18 (51): 7265-73. doi:10.1038/sj.onc.1203170. PMID 10602480.
Sambrano GR, Huang W, Faruqi T, et al. (2000). "Cathepsin G activates protease-activated receptor-4 in human platelets.". J. Biol. Chem. 275 (10): 6819-23. PMID 10702240.
Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin.". Nature 404 (6778): 609-13. doi:10.1038/35007085. PMID 10766244.
Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2.". J. Immunol. 167 (11): 6615-22. PMID 11714832.
Asokananthan N, Graham PT, Fink J, et al. (2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells.". J. Immunol. 168 (7): 3577-85. PMID 11907122.
Henriksen RA, Hanks VK (2002). "PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets.". Arterioscler. Thromb. Vasc. Biol. 22 (5): 861-6. PMID 12006403.
Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome.". Thromb. Haemost. 87 (4): 722-7. PMID 12008957.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin.". Biochem. Biophys. Res. Commun. 305 (1): 166-8. PMID 12732212.
Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). "Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP.". J. Thromb. Haemost. 1 (4): 798-804. PMID 12871418.
Wu CC, Hwang TL, Liao CH, et al. (2004). "The role of PAR4 in thrombin-induced thromboxane production in human platelets.". Thromb. Haemost. 90 (2): 299-308. doi:10.1267/THRO03020299. PMID 12888878.
Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains.". Mol. Cell. Biol. 23 (17): 6174-86. PMID 12917339.
Jacques SL, Kuliopulos A (2004). "Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.". Biochem. J. 376 (Pt 3): 733-40. doi:10.1042/BJ20030954. PMID 13678420.
Han Y, Nurden A, Combrié R, Pasquet JM (2004). "Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.". J. Thromb. Haemost. 1 (10): 2206-15. PMID 14521606.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub

[entrez-0] 1.0 ^1.1 Entrez Gene: F2RL3 coagulation factor II (thrombin) receptor-like 3.

[1]

v • d • e Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin like	Acetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin like	Brain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromone	Calcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / Smoothened	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

F2RL3

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