Prostaglandin D2 receptor

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The correct title of this article is Prostaglandin D2 receptor. It appears incorrectly here because of technical restrictions.


Prostaglandin D2 receptor (DP)
Identifiers
Symbol(s) PTGDR; AS1; ASRT1; DP; MGC49004
External IDs OMIM: 604687 MGI: 102966 Homologene: 736
RNA expression pattern

Image:PBB GE PTGDR 215894 at tn.png

More reference expression data

Orthologs
Human Mouse
Entrez 5729 19214
Ensembl ENSG00000168229 ENSMUSG00000071489
Uniprot Q13258 Q8CCM3
Refseq NM_000953 (mRNA)
NP_000944 (protein) 		NM_008962 (mRNA)
NP_032988 (protein)
Location Chr 14: 51.8 - 51.81 Mb Chr 14: 43.77 - 43.78 Mb
Pubmed search [1] [2]

Prostaglandin D2 receptor (DP), also known as PTGDR, is a receptor for prostaglandin D2, but also denotes the human gene encoding it.[1]



Contents

Mechanism

It is a G-protein-coupled receptor. The activity of it is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses.[1] It also causes vasodilation

See also

References

Further reading

  • Boyce JA (2004). "The role of mast cells in asthma.". Prostaglandins Leukot. Essent. Fatty Acids 69 (2-3): 195-205. PMID 12895603.
  • Chiba T, Kanda A, Ueki S, et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells.". Int. Arch. Allergy Immunol. 143 Suppl 1: 23-7. doi:10.1159/000101400. PMID 17541272.
  • Senior J, Sangha R, Baxter GS, et al. (1992). "In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium.". Br. J. Pharmacol. 107 (1): 215-21. PMID 1422574.
  • Boie Y, Sawyer N, Slipetz DM, et al. (1995). "Molecular cloning and characterization of the human prostanoid DP receptor.". J. Biol. Chem. 270 (32): 18910-6. PMID 7642548.
  • Ishikawa TO, Tamai Y, Rochelle JM, et al. (1997). "Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors.". Genomics 32 (2): 285-8. doi:10.1006/geno.1996.0118. PMID 8833158.
  • Kobayashi T, Ushikubi F, Narumiya S (2000). "Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis.". J. Biol. Chem. 275 (32): 24294-303. doi:10.1074/jbc.M002437200. PMID 10827082.
  • Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM (2001). "The human prostanoid DP receptor stimulates mucin secretion in LS174T cells.". Br. J. Pharmacol. 131 (8): 1537-45. doi:10.1038/sj.bjp.0703688. PMID 11139429.
  • Gervais FG, Cruz RP, Chateauneuf A, et al. (2002). "Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP.". J. Allergy Clin. Immunol. 108 (6): 982-8. doi:10.1067/mai.2001.119919. PMID 11742277.
  • Noguchi E, Shibasaki M, Kamioka M, et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes.". Clin. Exp. Allergy 32 (1): 93-6. PMID 12002745.
  • Hakonarson H, Bjornsdottir US, Halapi E, et al. (2002). "A major susceptibility gene for asthma maps to chromosome 14q24.". Am. J. Hum. Genet. 71 (3): 483-91. PMID 12119603.
  • Iwasaki M, Nagata K, Takano S, et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis.". J. Invest. Dermatol. 119 (3): 609-16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Moreland RB, Nehra A, Kim NN, et al. (2003). "Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle.". Int. J. Impot. Res. 14 (6): 446-52. doi:10.1038/sj.ijir.3900900. PMID 12494276.
  • Faveeuw C, Gosset P, Bureau F, et al. (2003). "Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways.". Eur. J. Immunol. 33 (4): 889-98. doi:10.1002/eji.200323330. PMID 12672054.
  • Angeli V, Staumont D, Charbonnier AS, et al. (2004). "Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses.". J. Immunol. 172 (6): 3822-9. PMID 15004188.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
  • Oguma T, Palmer LJ, Birben E, et al. (2004). "Role of prostanoid DP receptor variants in susceptibility to asthma.". N. Engl. J. Med. 351 (17): 1752-63. doi:10.1056/NEJMoa031785. PMID 15496624.
  • Spik I, Brénuchon C, Angéli V, et al. (2005). "Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse.". J. Immunol. 174 (6): 3703-8. PMID 15749909.
  • Hirano Y, Shichijo M, Deguchi M, et al. (2007). "Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells.". Eur. J. Pharmacol. 560 (1): 81-8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transmembrane receptor: G protein-coupled receptors
Class A: Rhodopsin likeAcetylcholine (M1, M2, M3, M4, M5) - Adrenergic (α1 (A, B, D), α2 (A, B, C), β1, β2, β3) - Adrenomedullin - Anaphylatoxin (C3a, C5a) - Angiotensin (1, 2) - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin (B1, B2) - Cannabinoid (CB1, CB2) - Chemokine - Cholecystokinin (A, B) - Dopamine (D1, D2, D3, D4, D5) - Eicosanoid (CysLT (1, 2), LTB4 (1, 2), FPRL1, OXE, Prostaglandin ((DP (1, 2), EP (1, 2, 3, 4), PGF, Prostacyclin, Thromboxane) - EBI2 - Endothelin (A, B) - Estrogen - Formyl peptide (1, L1, L2) - Free fatty acid (1, 2, 3, 4) - FSH - Galanin (1, 2, 3) - Gonadotropin-releasing hormone (1, 2) - GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 79, 82, 83, 84, 85, 87, 88, 92, 101, 103, 119, 120, 132, 135, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 172, 173, 174, 176, 182) - Ghrelin - Histamine (H1, H2, H3, H4) - Kisspeptin - Luteinizing hormone/choriogonadotropin - Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) - MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) - Melanocortin (1, 2, 3, 4, 5) - MCHR (1, 2) - Melatonin (1A, 1B)- Motilin - Neuromedin (B, U (1, 2)) - Neuropeptide (B/W (1, 2), FF (1, 2), S, Y (1, 2, 4, 5)) - Neurotensin (1, 2) - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory - Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) - Orexin (1, 2) - Oxytocin - Oxoglutarate - PAF - Prokineticin (1, 2) - Prolactin-releasing peptide - Protease-activated (1, 2, 3, 4) - Purinergics (Adenosine (A1, A2a, A2b, A3), P2Y, (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)) - Relaxin (1, 2, 3, 4) - Somatostatin (1, 2, 3, 4, 5) - Serotonin, all but 5-HT3 (5-HT1 (A, B, D, E, F), 5-HT2 (A, B, C), 5-HT (4, 5A, 6, 7)) - SREB - Succinate - TAAR (1, 2, 3, 5, 6, 8, 9) - Tachykinin (1, 2, 3) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2)
Class B: Secretin likeBrain-specific angiogenesis inhibitor (1, 2, 3) - Cadherin (1, 2, 3) - Calcitonin - CD97 - Corticotropin-releasing hormone (1, 2) - EMR (1, 2, 3) - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - PACAPR1- GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 157) - Latrophilin (1, 2, 3, ELTD1) - Parathyroid hormone (1, 2) - Secretin - Vasoactive intestinal peptide (1, 2)
Class C: Metabotropic glutamate / pheromoneCalcium-sensing receptor - GABA B (1, 2) - Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) - GPRC6A - GPR (156, 158, 179) - RAIG (1, 2, 3, 4) - Taste receptors (TAS1R (1, 2, 3) TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, 50))
Frizzled / SmoothenedFrizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10) - Smoothened

Acknowledgement and Attribution Regarding Sources of Content

Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

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