FZD2

Frizzled homolog 2 (Drosophila)
Identifiers
Symbol(s)	FZD2;
External IDs	OMIM: 600667 MGI: 1888513 Homologene: 20377
Gene ontology Molecular Function: • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding Cellular Component: • integral to plasma membrane • membrane Biological Process: • establishment of tissue polarity • G-protein coupled receptor protein signaling pathway • cell-cell signaling • multicellular organismal development • Wnt receptor signaling pathway • epithelial cell differentiation
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2535	57265
Ensembl	ENSG00000180340	ENSMUSG00000050288
Uniprot	Q14332	Q923Z9
Refseq	NM_001466 (mRNA) NP_001457 (protein)	NM_020510 (mRNA) NP_065256 (protein)
Location	Chr 17: 39.99 - 39.99 Mb	Chr 11: 102.42 - 102.42 Mb
Pubmed search	[1]	[2]

Frizzled homolog 2 (Drosophila), also known as FZD2, is a human gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary.

See also

• Frizzled

Further reading

• Zhao Z, Lee CC, Baldini A, Caskey CT (1995). "A human homologue of the Drosophila polarity gene frizzled has been identified and mapped to 17q21.1.". Genomics 27 (2): 370-3. doi:10.1006/geno.1995.1060. PMID 7558010.
• Wang Y, Macke JP, Abella BS, et al. (1996). "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled.". J. Biol. Chem. 271 (8): 4468-76. PMID 8626800.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770-5. PMID 9192640.
• Tanaka S, Akiyoshi T, Mori M, et al. (1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164-9. PMID 9707618.
• Sagara N, Toda G, Hirai M, et al. (1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7.". Biochem. Biophys. Res. Commun. 252 (1): 117-22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
• Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95.". FEBS Lett. 521 (1-3): 185-9. PMID 12067714.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Oishi I, Suzuki H, Onishi N, et al. (2004). "The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.". Genes Cells 8 (7): 645-54. PMID 12839624.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81-90. doi:10.1080/13816810490514270. PMID 15370539.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.