Neuropeptide Y receptor Y2

Neuropeptide Y receptor Y2
Identifiers
Symbol(s)	NPY2R;
External IDs	OMIM: 162642 MGI: 108418 Homologene: 701
Gene ontology Molecular Function: • rhodopsin-like receptor activity • peptide YY receptor activity • receptor activity • calcium channel regulator activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • G-protein signaling, adenylate cyclase inhibiting pathway • circadian rhythm • locomotory behavior • feeding behavior
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	4887	18167
Ensembl	ENSG00000185149	ENSMUSG00000028004
Uniprot	P49146	Q8BWV1
Refseq	NM_000910 (mRNA) NP_000901 (protein)	NM_008731 (mRNA) NP_032757 (protein)
Location	Chr 4: 156.35 - 156.36 Mb	Chr 3: 82.62 - 82.63 Mb
Pubmed search	[1]	[2]

Neuropeptide Y receptor Y2, also known as NPY2R, is a human gene.

See also

• Neuropeptide Y receptor

Further reading

• Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055-64. PMID 9001438.
• Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2-3): 173-87. PMID 12007534.
• Herzog H, Hort YJ, Ball HJ, et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems.". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794-8. PMID 1321422.
• Rose PM, Fernandes P, Lynch JS, et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor.". J. Biol. Chem. 270 (39): 22661-4. PMID 7559383.
• Gerald C, Walker MW, Vaysse PJ, et al. (1995). "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype.". J. Biol. Chem. 270 (45): 26758-61. PMID 7592910.
• Lynch JW, Lemos VS, Bucher B, et al. (1994). "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line.". J. Biol. Chem. 269 (11): 8226-33. PMID 8132547.
• Gehlert DR, Beavers LS, Johnson D, et al. (1996). "Expression cloning of a human brain neuropeptide Y Y2 receptor.". Mol. Pharmacol. 49 (2): 224-8. PMID 8632753.
• Yan H, Yang J, Marasco J, et al. (1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors.". Proc. Natl. Acad. Sci. U.S.A. 93 (10): 4661-5. PMID 8643460.
• Ammar DA, Eadie DM, Wong DJ, et al. (1997). "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene.". Genomics 38 (3): 392-8. PMID 8975716.
• Snow BE, Hall RA, Krumins AM, et al. (1998). "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.". J. Biol. Chem. 273 (28): 17749-55. PMID 9651375.
• Caberlotto L, Fuxe K, Rimland JM, et al. (1998). "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain.". Neuroscience 86 (1): 167-78. PMID 9692752.
• Goumain M, Voisin T, Lorinet AM, et al. (2001). "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning.". Mol. Pharmacol. 60 (1): 124-34. PMID 11408607.
• Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa.". Br. J. Pharmacol. 135 (6): 1505-12. doi:10.1038/sj.bjp.0704604. PMID 11906964.
• Uddman R, Möller S, Nilsson T, et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues.". Peptides 23 (5): 927-34. PMID 12084524.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Hyland NP, Sjöberg F, Tough IR, et al. (2004). "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues.". Br. J. Pharmacol. 139 (4): 863-71. doi:10.1038/sj.bjp.0705298. PMID 12813010.
• Hung CC, Pirie F, Luan J, et al. (2004). "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits.". Diabetes 53 (9): 2461-6. PMID 15331560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.