Somatostatin receptor 4

Somatostatin receptor 4
Identifiers
Symbol(s)	SSTR4;
External IDs	OMIM: 182454 MGI: 105372 Homologene: 20286
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • somatostatin receptor activity • melanin-concentrating hormone receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein signaling, coupled to cyclic nucleotide second messenger • neuropeptide signaling pathway • negative regulation of cell proliferation
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	6754	20608
Ensembl	ENSG00000132671	ENSMUSG00000037014
Uniprot	P31391	Q8BQ97
Refseq	NM_001052 (mRNA) NP_001043 (protein)	NM_009219 (mRNA) NP_033245 (protein)
Location	Chr 20: 22.96 - 22.97 Mb	Chr 2: 148.09 - 148.09 Mb
Pubmed search	[1]	[2]

Somatostatin receptor 4, also known as SSTR4, is a human gene.

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.

See also

• Somatostatin receptor

Further reading

• Patel YC (1999). "Somatostatin and its receptor family.". Frontiers in neuroendocrinology 20 (3): 157-98. doi:10.1006/frne.1999.0183. PMID 10433861.
• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251-5. PMID 1346068.
• Demchyshyn LL, Srikant CB, Sunahara RK, et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20.". Mol. Pharmacol. 43 (6): 894-901. PMID 8100352.
• Yasuda K, Espinosa R, Davis EM, et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.". Genomics 17 (3): 785-6. doi:10.1006/geno.1993.1410. PMID 8244401.
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype.". Biochem. Biophys. Res. Commun. 195 (2): 844-52. PMID 8373420.
• Kaupmann K, Bruns C, Hoyer D, et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain.". FEBS Lett. 331 (1-2): 53-9. PMID 8405411.
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms.". Genomics 15 (2): 449-52. doi:10.1006/geno.1993.1088. PMID 8449518.
• Rohrer L, Raulf F, Bruns C, et al. (1993). "Cloning and characterization of a fourth human somatostatin receptor.". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 4196-200. PMID 8483934.
• Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4.". Biochem. Biophys. Res. Commun. 193 (2): 648-52. PMID 8512564.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide.". Biochem. Biophys. Res. Commun. 232 (1): 157-63. doi:10.1006/bbrc.1997.6252. PMID 9125122.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin.". Genomics 42 (3): 499-506. doi:10.1006/geno.1997.4763. PMID 9205124.
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours.". Eur. J. Clin. Invest. 27 (8): 639-44. PMID 9279525.
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest.". Mol. Endocrinol. 13 (1): 82-90. PMID 9892014.
• Forssell-Aronsson EB, Nilsson O, Bejegård SA, et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors.". J. Nucl. Med. 41 (4): 636-42. PMID 10768564.
• Zatelli MC, Tagliati F, Taylor JE, et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt.". J. Clin. Endocrinol. Metab. 86 (5): 2161-9. PMID 11344221.
• Talme T, Ivanoff J, Hägglund M, et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3.". Clin. Exp. Immunol. 125 (1): 71-9. PMID 11472428.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175-9. PMID 11753241.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis.". Virchows Arch. 440 (5): 461-75. doi:10.1007/s00428-002-0609-x. PMID 12021920.

External links

• IUPHAR Receptor Database - Somatostatin Receptors
• MeSH somatostatin+receptor+subtype-4

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.