Neuropeptides B/W receptor 1

Neuropeptides B/W receptor 1
Identifiers
Symbol(s)	NPBWR1; GPR7; MGC129755
External IDs	OMIM: 600730 MGI: 891989 Homologene: 21096
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • opioid receptor activity • protein binding Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • neuropeptide signaling pathway • synaptic transmission • regulation of metabolic process
Orthologs
	Human	Mouse
Entrez	2831	226304
Ensembl	ENSG00000183729	ENSMUSG00000033774
Uniprot	P48145	P49681
Refseq	NM_005285 (mRNA) NP_005276 (protein)	XM_136404 (mRNA) XP_136404 (protein)
Location	Chr 8: 54.01 - 54.02 Mb	Chr 1: 5.91 - 5.91 Mb
Pubmed search	[1]	[2]

Neuropeptides B/W receptor 1, also known as NPBWR1, is a human gene.

Further reading

• O'Dowd BF, Scheideler MA, Nguyen T, et al. (1995). "The cloning and chromosomal mapping of two novel human opioid-somatostatin-like receptor genes, GPR7 and GPR8, expressed in discrete areas of the brain.". Genomics 28 (1): 84-91. PMID 7590751.
• Fujii R, Yoshida H, Fukusumi S, et al. (2002). "Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.". J. Biol. Chem. 277 (37): 34010-6. doi:10.1074/jbc.M205883200. PMID 12118011.
• Shimomura Y, Harada M, Goto M, et al. (2002). "Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.". J. Biol. Chem. 277 (39): 35826-32. doi:10.1074/jbc.M205337200. PMID 12130646.
• Brezillon S, Lannoy V, Franssen JD, et al. (2003). "Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.". J. Biol. Chem. 278 (2): 776-83. doi:10.1074/jbc.M206396200. PMID 12401809.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Tanaka H, Yoshida T, Miyamoto N, et al. (2003). "Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 6251-6. doi:10.1073/pnas.0837789100. PMID 12719537.
• Zaratin PF, Quattrini A, Previtali SC, et al. (2005). "Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.". Mol. Cell. Neurosci. 28 (1): 55-63. doi:10.1016/j.mcn.2004.08.010. PMID 15607941.
• Mazzocchi G, Rebuffat P, Ziolkowska A, et al. (2005). "G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.". J. Clin. Endocrinol. Metab. 90 (6): 3466-71. doi:10.1210/jc.2004-2132. PMID 15797961.
• Cottrell S, Jung K, Kristiansen G, et al. (2007). "Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.". J. Urol. 177 (5): 1753-8. doi:10.1016/j.juro.2007.01.010. PMID 17437806.