GPR4

G protein-coupled receptor 4
Identifiers
Symbol(s)	GPR4;
External IDs	OMIM: 600551 MGI: 2441992 Homologene: 3867
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	2828	319197
Ensembl	ENSG00000177464	ENSMUSG00000044317
Uniprot	P46093	na
Refseq	NM_005282 (mRNA) NP_005273 (protein)	NM_175668 (mRNA) NP_783599 (protein)
Location	Chr 19: 50.78 - 50.8 Mb	Chr 7: 18.37 - 18.38 Mb
Pubmed search	[1]	[2]

G protein-coupled receptor 4, also known as GPR4, is a human gene.

Further reading

• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.". FEBS Lett. 375 (1-2): 121-4. PMID 7498459.
• Heiber M, Docherty JM, Shah G, et al. (1995). "Isolation of three novel human genes encoding G protein-coupled receptors.". DNA Cell Biol. 14 (1): 25-35. PMID 7832990.
• Mahadevan MS, Baird S, Bailly JE, et al. (1996). "Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3.". Genomics 30 (1): 84-8. doi:10.1006/geno.1995.0013. PMID 8595909.
• Zhu K, Baudhuin LM, Hong G, et al. (2001). "Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.". J. Biol. Chem. 276 (44): 41325-35. doi:10.1074/jbc.M008057200. PMID 11535583.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Lum H, Qiao J, Walter RJ, et al. (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786-9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.
• Ludwig MG, Vanek M, Guerini D, et al. (2003). "Proton-sensing G-protein-coupled receptors.". Nature 425 (6953): 93-8. doi:10.1038/nature01905. PMID 12955148.
• Bektas M, Barak LS, Jolly PS, et al. (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.". Biochemistry 42 (42): 12181-91. doi:10.1021/bi035051y. PMID 14567679.
• Sin WC, Zhang Y, Zhong W, et al. (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.". Oncogene 23 (37): 6299-303. doi:10.1038/sj.onc.1207838. PMID 15221007.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Kim KS, Ren J, Jiang Y, et al. (2005). "GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.". FASEB J. 19 (7): 819-21. doi:10.1096/fj.04-2988fje. PMID 15857892.
• Qiao J, Huang F, Naikawadi RP, et al. (2006). "Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91-101. doi:10.1152/ajplung.00508.2005. PMID 16461426.
• Huang F, Mehta D, Predescu S, et al. (2007). "A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.". Endothelium 14 (1): 25-34. doi:10.1080/10623320601177288. PMID 17364894.
• Zou Y, Kim CH, Chung JH, et al. (2007). "Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.". FEBS J. 274 (10): 2573-84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524.
• Tobo M, Tomura H, Mogi C, et al. (2007). "Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.". Cell. Signal. 19 (8): 1745-53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.