Histamine H4 receptor
- The correct title of this article is Histamine H4 receptor. It appears incorrectly here because of technical restrictions.
histamine receptor H4
|Locus||Chr. 18 q11.2|
H4 is highly expressed in bone marrow and white blood cells and regulates zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model along with L-selectin. It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea.
High affinity substances
The following substances have been found to bind with high affinity to this receptor:
Moderate affinity substances
The following substances have been found to bind with moderate affinity to this receptor:
Weak affinity substances
The following substances have been found to bind with weak affinity to this receptor:
- ↑ Oda T, Morikawa N, Saito Y, Masuho Y, Matsumoto S (2000). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". J. Biol. Chem. 275 (47): 36781–6. doi:10.1074/jbc.M006480200. PMID 10973974.
- ↑ Nakamura T, Itadani H, Hidaka Y, Ohta M, Tanaka K (2000). "Molecular cloning and characterization of a new human histamine receptor, HH4R". Biochem. Biophys. Res. Commun. 279 (2): 615–20. doi:10.1006/bbrc.2000.4008. PMID 11118334.
- ↑ Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF (2001). "Discovery of a novel member of the histamine receptor family". Mol. Pharmacol. 59 (3): 427–33. PMID 11179435.
- ↑ Takeshita K, Bacon KB, Gantner F (2004). "Critical role of L-selectin and histamine H4 receptor in zymosan-induced neutrophil recruitment from the bone marrow: comparison with carrageenan". J. Pharmacol. Exp. Ther. 310 (1): 272–80. doi:10.1124/jpet.103.063776. PMID 14996947.
- ↑ Bioreagents.com: Histamine H4 Receptor
- ↑ Hofstra CL, Desai PJ, Thurmond RL, Fung-Leung WP (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". J. Pharmacol. Exp. Ther. 305 (3): 1212–21. doi:10.1124/jpet.102.046581. PMID 12626656.
- ↑ 7.0 7.1 InterPro: IPR008102 Histamine H4 receptor
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