CD46

CD46 molecule, complement regulatory protein
PDB rendering based on 1ckl.
Available structures: 1ckl, 2o39
Identifiers
Symbol(s)	CD46; MCP; MGC26544; MIC10; TLX; TRA2.10
External IDs	OMIM: 120920 MGI: 1203290 Homologene: 7832
Gene ontology Molecular Function: • receptor activity Cellular Component: • plasma membrane • integral to plasma membrane Biological Process: • complement activation, classical pathway • single fertilization • innate immune response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	4179	17221
Ensembl	ENSG00000117335	ENSMUSG00000016493
Uniprot	P15529	O88174
Refseq	NM_002389 (mRNA) NP_002380 (protein)	NM_010778 (mRNA) NP_034908 (protein)
Location	Chr 1: 205.99 - 206.04 Mb	Chr 1: 196.76 - 196.79 Mb
Pubmed search	[1]	[2]

CD46 is an inhibitory complement receptor.

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.

External links

• MeSH CD46+antigen