FZD3

Frizzled homolog 3 (Drosophila)
Identifiers
Symbol(s)	FZD3; Fz-3; hFz3
External IDs	OMIM: 606143 MGI: 108476 Homologene: 23004
Gene ontology Molecular Function: • receptor activity • non-G-protein coupled 7TM receptor activity • G-protein coupled receptor activity • protein binding • Wnt receptor activity Cellular Component: • integral to plasma membrane • membrane • apical part of cell Biological Process: • establishment of planar polarity • neural tube closure • G-protein coupled receptor protein signaling pathway • Wnt receptor signaling pathway • multicellular organismal development • cell proliferation • inner ear morphogenesis
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7976	14365
Ensembl	ENSG00000104290	ENSMUSG00000007989
Uniprot	Q9NPG1	Q3TUV1
Refseq	NM_017412 (mRNA) NP_059108 (protein)	NM_021458 (mRNA) NP_067433 (protein)
Location	Chr 8: 28.41 - 28.49 Mb	Chr 14: 64.16 - 64.22 Mb
Pubmed search	[1]	[2]

Frizzled homolog 3 (Drosophila), also known as FZD3, is a human gene.

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. The function of this protein is unknown, although it may play a role in mammalian hair follicle development.

See also

• Frizzled

Further reading

• Katoh M (2002). "GIPC gene family (Review).". Int. J. Mol. Med. 9 (6): 585-9. PMID 12011974.
• Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action.". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770-5. PMID 9192640.
• Wright M, Aikawa M, Szeto W, Papkoff J (1999). "Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells.". Biochem. Biophys. Res. Commun. 263 (2): 384-8. doi:10.1006/bbrc.1999.1344. PMID 10491302.
• Kirikoshi H, Koike J, Sagara N, et al. (2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21.". Biochem. Biophys. Res. Commun. 271 (1): 8-14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
• Sala CF, Formenti E, Terstappen GC, Caricasole A (2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3).". Biochem. Biophys. Res. Commun. 273 (1): 27-34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
• Hung BS, Wang XQ, Cam GR, Rothnagel JA (2001). "Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes.". J. Invest. Dermatol. 116 (6): 940-6. doi:10.1046/j.1523-1747.2001.01336.x. PMID 11407985.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Katsu T, Ujike H, Nakano T, et al. (2004). "The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia.". Neurosci. Lett. 353 (1): 53-6. PMID 14642436.
• Zhang Y, Yu X, Yuan Y, et al. (2005). "Positive association of the human frizzled 3 (FZD3) gene haplotype with schizophrenia in Chinese Han population.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 16-9. doi:10.1002/ajmg.b.30076. PMID 15274031.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
• Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R).". Ophthalmic Genet. 25 (2): 81-90. doi:10.1080/13816810490514270. PMID 15370539.
• Hashimoto R, Suzuki T, Iwata N, et al. (2005). "Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders.". Journal of neural transmission (Vienna, Austria : 1996) 112 (2): 303-7. doi:10.1007/s00702-004-0264-2. PMID 15657645.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.