TLR 1

Toll-like receptor 1
250px
PDB rendering based on 1fyv.
Available structures: 1fyv
Identifiers
Symbol(s)	TLR1; CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; TIL; rsc786
External IDs	OMIM: 601194 MGI: 1341295 Homologene: 20694
Gene ontology Molecular Function: • transmembrane receptor activity • protein binding • triacylated lipoprotein binding Cellular Component: • plasma membrane • integral to plasma membrane • phagocytic vesicle Biological Process: • inflammatory response • signal transduction • activation of NF-kappaB-inducing kinase • macrophage activation • detection of triacylated bacterial lipoprotein • positive regulation of tumor necrosis factor biosynthetic process • innate immune response • positive regulation of interleukin-6 biosynthetic process
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	7096	21897
Ensembl	ENSG00000174125	ENSMUSG00000044827
Uniprot	Q15399	Q6A0E8
Refseq	XM_001129777 (mRNA) XP_001129777 (protein)	NM_030682 (mRNA) NP_109607 (protein)
Location	Chr 4: 38.47 - 38.48 Mb	Chr 5: 65.2 - 65.21 Mb
Pubmed search	[1]	[2]

TLR 1 is a member of the Toll-like receptor family of pattern recognition receptors of the innate immune system. TLR1 recognizes pathogen-associated molecular pattern with a specificity for gram-positive bacteria. TLR1 has also been designated as CD281 (cluster of differentiation 281).

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene.

Further reading

• Lien E, Ingalls RR (2002). "Toll-like receptors.". Crit. Care Med. 30 (1 Suppl): S1-11. PMID 11782555.

External links

• MeSH Toll-Like+Receptor+1