CD83

CD83 molecule
Identifiers
Symbol(s)	CD83; BL11; HB15
External IDs	OMIM: 604534 MGI: 1328316 Homologene: 3121
Gene ontology Cellular Component: • plasma membrane • integral to plasma membrane Biological Process: • defense response • humoral immune response • signal transduction
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	9308	12522
Ensembl	ENSG00000112149	ENSMUSG00000015396
Uniprot	Q01151	na
Refseq	NM_001040280 (mRNA) NP_001035370 (protein)	NM_009856 (mRNA) NP_033986 (protein)
Location	Chr 6: 14.23 - 14.25 Mb	Chr 13: 43.8 - 43.81 Mb
Pubmed search	[1]	[2]

CD83 (Cluster of Differentiation 83) is a human protein encoded by the CD83 gene.

See also

• Cluster of differentiation

Further reading

• Lechmann M, Berchtold S, Hauber J, Steinkasserer A (2002). "CD83 on dendritic cells: more than just a marker for maturation.". Trends Immunol. 23 (6): 273-5. PMID 12072358.
• Zhou LJ, Schwarting R, Smith HM, Tedder TF (1992). "A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.". J. Immunol. 149 (2): 735-42. PMID 1378080.
• Zhou LJ, Tedder TF (1995). "Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.". J. Immunol. 154 (8): 3821-35. PMID 7706722.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
• Kozlow EJ, Wilson GL, Fox CH, Kehrl JH (1993). "Subtractive cDNA cloning of a novel member of the Ig gene superfamily expressed at high levels in activated B lymphocytes.". Blood 81 (2): 454-61. PMID 8422464.
• de la Fuente MA, Pizcueta P, Nadal M, et al. (1997). "CD84 leukocyte antigen is a new member of the Ig superfamily.". Blood 90 (6): 2398-405. PMID 9310491.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
• Olavesen MG, Bentley E, Mason RV, et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25.". Genomics 46 (2): 303-6. doi:10.1006/geno.1997.5032. PMID 9417921.
• Twist CJ, Beier DR, Disteche CM, et al. (1998). "The mouse Cd83 gene: structure, domain organization, and chromosome localization.". Immunogenetics 48 (6): 383-93. PMID 9799334.
• Berchtold S, Mühl-Zürbes P, Heufler C, et al. (1999). "Cloning, recombinant expression and biochemical characterization of the murine CD83 molecule which is specifically upregulated during dendritic cell maturation.". FEBS Lett. 461 (3): 211-6. PMID 10567699.
• Scholler N, Hayden-Ledbetter M, Hellström KE, et al. (2001). "CD83 is a sialic acid-binding Ig-like lectin (Siglec) adhesion receptor that binds monocytes and a subset of activated CD8+ T cells.". J. Immunol. 166 (6): 3865-72. PMID 11238630.
• Fanales-Belasio E, Moretti S, Nappi F, et al. (2002). "Native HIV-1 Tat protein targets monocyte-derived dendritic cells and enhances their maturation, function, and antigen-specific T cell responses.". J. Immunol. 168 (1): 197-206. PMID 11751963.
• Berchtold S, Mühl-Zürbes P, Maczek E, et al. (2003). "Cloning and characterization of the promoter region of the human CD83 gene.". Immunobiology 205 (3): 231-46. PMID 12182451.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• te Velde AA, van Kooyk Y, Braat H, et al. (2003). "Increased expression of DC-SIGN+IL-12+IL-18+ and CD83+IL-12-IL-18- dendritic cell populations in the colonic mucosa of patients with Crohn's disease.". Eur. J. Immunol. 33 (1): 143-51. doi:10.1002/immu.200390017. PMID 12594843.
• Dudziak D, Kieser A, Dirmeier U, et al. (2003). "Latent membrane protein 1 of Epstein-Barr virus induces CD83 by the NF-kappaB signaling pathway.". J. Virol. 77 (15): 8290-8. PMID 12857898.
• Hock BD, Haring LF, Steinkasserer A, et al. (2004). "The soluble form of CD83 is present at elevated levels in a number of hematological malignancies.". Leuk. Res. 28 (3): 237-41. PMID 14687618.
• Sénéchal B, Boruchov AM, Reagan JL, et al. (2004). "Infection of mature monocyte-derived dendritic cells with human cytomegalovirus inhibits stimulation of T-cell proliferation via the release of soluble CD83.". Blood 103 (11): 4207-15. doi:10.1182/blood-2003-12-4350. PMID 14962896.
• Cao W, Lee SH, Lu J (2005). "CD83 is preformed inside monocytes, macrophages and dendritic cells, but it is only stably expressed on activated dendritic cells.". Biochem. J. 385 (Pt 1): 85-93. doi:10.1042/BJ20040741. PMID 15320871.