Brain-specific angiogenesis inhibitor 2

Brain-specific angiogenesis inhibitor 2
Identifiers
Symbol(s)	BAI2;
External IDs	OMIM: 602683 MGI: 2451244 Homologene: 1288
Gene ontology Molecular Function: • receptor activity • G-protein coupled receptor activity • brain-specific angiogenesis inhibitor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • neuropeptide signaling pathway
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	576	230775
Ensembl	ENSG00000121753	ENSMUSG00000028782
Uniprot	O60241	Q80T36
Refseq	NM_001703 (mRNA) NP_001694 (protein)	NM_173071 (mRNA) NP_775094 (protein)
Location	Chr 1: 31.97 - 32 Mb	Chr 4: 129.49 - 129.52 Mb
Pubmed search	[1]	[2]

Brain-specific angiogenesis inhibitor 2, also known as BAI2, is a human gene.

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

Further reading

• Shiratsuchi T, Nishimori H, Ichise H, et al. (1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).". Cytogenet. Cell Genet. 79 (1-2): 103-8. PMID 9533023.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387-90. doi:10.1074/jbc.C000490200. PMID 10964907.
• Kee HJ, Koh JT, Kim MY, et al. (2002). "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.". J. Cereb. Blood Flow Metab. 22 (9): 1054-67. doi:10.1097/00004647-200209000-00003. PMID 12218411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Petersen HH, Hilpert J, Militz D, et al. (2003). "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.". J. Cell. Sci. 116 (Pt 3): 453-61. PMID 12508107.
• Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell Proteomics 1 (12): 947-55. PMID 12543931.
• Nagaraja GM, Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.". Biochem. Biophys. Res. Commun. 313 (3): 654-65. PMID 14697242.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23-33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.