OPN5

Opsin 5
Identifiers
Symbol(s)	OPN5; GPR136; PGR12; TMEM13
External IDs	OMIM: 609042 MGI: 2662912 Homologene: 72341
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • visual perception • phototransduction • protein-chromophore linkage • response to stimulus
Orthologs
	Human	Mouse
Entrez	221391	353344
Ensembl	ENSG00000124818	ENSMUSG00000043972
Uniprot	Q6U736	Q059L5
Refseq	NM_001030051 (mRNA) NP_001025222 (protein)	NM_181753 (mRNA) NP_861418 (protein)
Location	Chr 6: 47.86 - 47.9 Mb	Chr 17: 42.02 - 42.07 Mb
Pubmed search	[1]	[2]

Opsin 5, also known as OPN5, is a human gene.

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this gene may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants encoding different isoforms.

See also

• Opsin

Further reading

• Terakita A (2006). "The opsins.". Genome Biol. 6 (3): 213. doi:10.1186/gb-2005-6-3-213. PMID 15774036.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse.". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903-8. doi:10.1073/pnas.0230374100. PMID 12679517.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805-11. doi:10.1038/nature02055. PMID 14574404.
• Fredriksson R, Höglund PJ, Gloriam DE, et al. (2003). "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives.". FEBS Lett. 554 (3): 381-8. PMID 14623098.
• Tarttelin EE, Bellingham J, Hankins MW, et al. (2003). "Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.". FEBS Lett. 554 (3): 410-6. PMID 14623103.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub