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tumor necrosis factor (ligand) superfamily, member 11
Symbol TNFSF11
Entrez 8600
HUGO 11926
OMIM 602642
RefSeq NM_003701
UniProt O14788
Other data
Locus Chr. 13 q14

RANKL (Receptor Activator for Nuclear Factor κ B Ligand), also known as TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and ODF (osteoclast differentiation factor) is a molecule important in bone metabolism. This natural and necessary surface-bound molecule activates osteoclasts, cells involved in bone resorption. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and osteomyelitis. RANKL also has a function in the immune system, where it is expressed by T helper cells and is thought to be involved in dendritic cell maturation.

See also


  • Whyte M (2006). "The long and the short of bone therapy". N Engl J Med. 354 (8): 860–3. PMID 16495400.  link

External links