CD22
| CD22 molecule
| |
| Identifiers | |
| Symbol | CD22 |
| Entrez | 933 |
| HUGO | 1643 |
| OMIM | 107266 |
| RefSeq | NM_001771 |
| UniProt | P20273 |
| Other data | |
| Locus | Chr. 19 q13.1 |
CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins.[1] Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases.
CD22 is a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. The presence of Ig domains makes CD22 a member of the immunoglobulin superfamily. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling.
EBV (Ebstein Bar Virus) is known to bind to the B lymphocyte via the CD22 receptor.
An immunotoxin, BL22, that targets this receptor is being tested at the NIH.[1]
External links
References
- ↑ Crocker P, Clark E, Filbin M, Gordon S, Jones Y, Kehrl J, Kelm S, Le Douarin N, Powell L, Roder J, Schnaar R, Sgroi D, Stamenkovic K, Schauer R, Schachner M, van den Berg T, van der Merwe P, Watt S, Varki A (1998). "Siglecs: a family of sialic-acid binding lectins". Glycobiology 8 (2): v. PMID 9498912.
Proteins: clusters of differentiation (see also list of human clusters of differentiation) | |
|---|---|
| 1-50 | CD1 (CD1a-c, CD1d) - CD2 - CD3 - CD4 - CD5 - CD8 - CD9 - CD10 - CD11 (CD11a, CD11b, CD11c) - CD13 - CD14 - CD15 - CD16 - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 - CD33 - CD34 - CD35 - CD36 - CD37 -CD38 - CD40 - CD43 - CD44 - CD45 - CD46 - CD49 (CD49a, CD49b, CD49c, CD49d) |
| 51-100 | CD52 - CD53 - CD54 - CD55 - CD56 - CD58 - CD59 - CD61 - CD62 (CD62E, CD62L, CD62P) - CD63 - CD64 - CD66e - CD68 - CD70 - CD71 - CD72 - CD79 - CD80 - CD81 - CD82 - CD83 - CD86 - CD88 - CD89 - CD90 - CD94 - CD95 - CD97 - CD98 |
| 101-350 | CD103 - CD106 - CD114 - CD116 - CD117 - CD118 - CD120 - CD122 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD137 - CD138 - CD141 - CD142 - CD143 - CD146 - CD147 - CD151 - CD152 - CD153 - CD154 - CD155 - CD162 - CD164 - CD169 - CD184 - CD206 - CD209 - CD257 - CD278 - CD281 - CD282 - CD283 - CD304 |
Membrane proteins: cell adhesion molecules | |
|---|---|
| IgSF | N-CAM (Myelin protein zero) - ICAM (1, 4) - VCAM-1 - PE-CAM - L1-CAM |
| Cadherins | Desmoglein - T-cadherin |
| Selectins | E-selectin - L-selectin - P-selectin |
| Integrins | LFA-1 - Integrin alphaXbeta2 - Macrophage-1 antigen - VLA-4 - Glycoprotein IIb/IIIa (Note: integrins not always classified as CAMs) |
| Other | Carcinoembryonic antigen - CD22 - CD24 - CD44 - CD146 - CD164 |
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