TAS1R3

Taste receptor, type 1, member 3
Identifiers
Symbol(s)	TAS1R3; T1R3
External IDs	OMIM: 605865 MGI: 1933547 Homologene: 12890
Gene ontology Molecular Function: • receptor activity • metabotropic glutamate, GABA-B-like receptor activity • taste receptor activity • protein heterodimerization activity Cellular Component: • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • response to stimulus • sensory perception of sweet taste • sensory perception of umami taste
Orthologs
	Human	Mouse
Entrez	83756	83771
Ensembl	ENSG00000169962	ENSMUSG00000029072
Uniprot	Q7RTX0	Q925D8
Refseq	NM_152228 (mRNA) NP_689414 (protein)	NM_031872 (mRNA) NP_114078 (protein)
Location	Chr 1: 1.26 - 1.26 Mb	Chr 4: 154.7 - 154.71 Mb
Pubmed search	[1]	[2]

Taste receptor, type 1, member 3, also known as TAS1R3, is a human gene.

The TAS1R3 gene encodes the human homolog of mouse Sac, a major determinant of differences between sweet-sensitive and -insensitive mouse strains in their responsiveness to sucrose, saccharine, and other sweeteners.[supplied by OMIM]

See also

• Taste receptor

Further reading

• Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS (2007). "The receptors and cells for mammalian taste.". Nature 444 (7117): 288-94. doi:10.1038/nature05401. PMID 17108952.
• Montmayeur JP, Liberles SD, Matsunami H, Buck LB (2001). "A candidate taste receptor gene near a sweet taste locus.". Nat. Neurosci. 4 (5): 492-8. doi:10.1038/87440. PMID 11319557.
• Max M, Shanker YG, Huang L, et al. (2001). "Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac.". Nat. Genet. 28 (1): 58-63. doi:10.1038/88270. PMID 11326277.
• Nelson G, Chandrashekar J, Hoon MA, et al. (2002). "An amino-acid taste receptor.". Nature 416 (6877): 199-202. doi:10.1038/nature726. PMID 11894099.
• Li X, Staszewski L, Xu H, et al. (2002). "Human receptors for sweet and umami taste.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4692-6. doi:10.1073/pnas.072090199. PMID 11917125.
• Spadaccini R, Trabucco F, Saviano G, et al. (2003). "The mechanism of interaction of sweet proteins with the T1R2-T1R3 receptor: evidence from the solution structure of G16A-MNEI.". J. Mol. Biol. 328 (3): 683-92. PMID 12706725.
• Ariyasu T, Matsumoto S, Kyono F, et al. (2004). "Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose.". In Vitro Cell. Dev. Biol. Anim. 39 (1-2): 80-8. doi:<0080:TRTIAE>2.0.CO;2 10.1290/1543-706X(2003)039<0080:TRTIAE>2.0.CO;2. PMID 12892531.
• Jiang P, Ji Q, Liu Z, et al. (2004). "The cysteine-rich region of T1R3 determines responses to intensely sweet proteins.". J. Biol. Chem. 279 (43): 45068-75. doi:10.1074/jbc.M406779200. PMID 15299024.
• Xu H, Staszewski L, Tang H, et al. (2005). "Different functional roles of T1R subunits in the heteromeric taste receptors.". Proc. Natl. Acad. Sci. U.S.A. 101 (39): 14258-63. doi:10.1073/pnas.0404384101. PMID 15353592.
• Taniguchi K (2005). "Expression of the sweet receptor protein, T1R3, in the human liver and pancreas.". J. Vet. Med. Sci. 66 (11): 1311-4. PMID 15585941.
• Jiang P, Cui M, Zhao B, et al. (2005). "Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste.". J. Biol. Chem. 280 (15): 15238-46. doi:10.1074/jbc.M414287200. PMID 15668251.
• Galindo-Cuspinera V, Winnig M, Bufe B, et al. (2006). "A TAS1R receptor-based explanation of sweet 'water-taste'.". Nature 441 (7091): 354-7. doi:10.1038/nature04765. PMID 16633339.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
• Behrens M, Bartelt J, Reichling C, et al. (2006). "Members of RTP and REEP gene families influence functional bitter taste receptor expression.". J. Biol. Chem. 281 (29): 20650-9. doi:10.1074/jbc.M513637200. PMID 16720576.
• Koizumi A, Nakajima K, Asakura T, et al. (2007). "Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain.". Biochem. Biophys. Res. Commun. 358 (2): 585-9. doi:10.1016/j.bbrc.2007.04.171. PMID 17499612.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.