OPN3

Opsin 3 (encephalopsin, panopsin)
Identifiers
Symbol(s)	OPN3; ECPN
External IDs	OMIM: 606695 MGI: 1338022 Homologene: 40707
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • G-protein coupled photoreceptor activity Cellular Component: • integral to plasma membrane • membrane • integral to membrane Biological Process: • signal transduction • G-protein coupled receptor protein signaling pathway • visual perception • phototransduction • protein-chromophore linkage • regulation of circadian rhythm • response to stimulus
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	23596	13603
Ensembl	ENSG00000054277	ENSMUSG00000026525
Uniprot	Q9H1Y3	Q3KR48
Refseq	NM_001030011 (mRNA) NP_001025182 (protein)	NM_010098 (mRNA) NP_034228 (protein)
Location	Chr 1: 239.82 - 239.87 Mb	Chr 1: 177.5 - 177.53 Mb
Pubmed search	[1]	[2]

Opsin 3 (encephalopsin, panopsin), also known as OPN3, is a human gene.

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. Alternative splicing results in multiple transcript variants encoding different isoforms.

See also

• Opsin

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
• Blackshaw S, Snyder SH (1999). "Encephalopsin: a novel mammalian extraretinal opsin discretely localized in the brain.". J. Neurosci. 19 (10): 3681-90. PMID 10234000.
• Halford S, Freedman MS, Bellingham J, et al. (2001). "Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43.". Genomics 72 (2): 203-8. doi:10.1006/geno.2001.6469. PMID 11401433.
• Halford S, Bellingham J, Ocaka L, et al. (2002). "Assignment of panopsin (OPN3) to human chromosome band 1q43 by in situ hybridization and somatic cell hybrids.". Cytogenet. Cell Genet. 95 (3-4): 234-5. PMID 12063405.
• Kasper G, Taudien S, Staub E, et al. (2003). "Different structural organization of the encephalopsin gene in man and mouse.". Gene 295 (1): 27-32. PMID 12242008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Alam NA, Gorman P, Jaeger EE, et al. (2004). "Germline deletions of EXO1 do not cause colorectal tumors and lesions which are null for EXO1 do not have microsatellite instability.". Cancer Genet. Cytogenet. 147 (2): 121-7. PMID 14623461.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain. Template:Membrane-protein-stub