P2RY1

Purinergic receptor P2Y, G-protein coupled, 1
Identifiers
Symbol(s)	P2RY1; P2Y1
External IDs	OMIM: 601167 MGI: 105049 Homologene: 1926
Gene ontology Molecular Function: • rhodopsin-like receptor activity • receptor activity • purinergic nucleotide receptor activity, G-protein coupled Cellular Component: • integral to plasma membrane • membrane Biological Process: • G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) • blood coagulation
RNA expression pattern
250px More reference expression data
Orthologs
	Human	Mouse
Entrez	5028	18441
Ensembl	ENSG00000169860	ENSMUSG00000027765
Uniprot	P47900	Q544J5
Refseq	NM_002563 (mRNA) NP_002554 (protein)	NM_008772 (mRNA) NP_032798 (protein)
Location	Chr 3: 154.04 - 154.04 Mb	Chr 3: 61.09 - 61.1 Mb
Pubmed search	[1]	[2]

Purinergic receptor P2Y, G-protein coupled, 1, also known as P2RY1, is a human gene.

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

See also

• P2Y receptor

Further reading

• Ayyanathan K, Webbs TE, Sandhu AK, et al. (1996). "Cloning and chromosomal localization of the human P2Y1 purinoceptor.". Biochem. Biophys. Res. Commun. 218 (3): 783-8. doi:10.1006/bbrc.1996.0139. PMID 8579591.
• Janssens R, Communi D, Pirotton S, et al. (1996). "Cloning and tissue distribution of the human P2Y1 receptor.". Biochem. Biophys. Res. Commun. 221 (3): 588-93. doi:10.1006/bbrc.1996.0640. PMID 8630005.
• Léon C, Vial C, Cazenave JP, Gachet C (1996). "Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor.". Gene 171 (2): 295-7. PMID 8666290.
• Léon C, Hechler B, Vial C, et al. (1997). "The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells.". FEBS Lett. 403 (1): 26-30. PMID 9038354.
• Ayyanathan K, Naylor SL, Kunapuli SP (1997). "Structural characterization and fine chromosomal mapping of the human P2Y1 purinergic receptor gene (P2RY1).". Somat. Cell Mol. Genet. 22 (5): 419-24. PMID 9039850.
• Maier R, Glatz A, Mosbacher J, Bilbe G (1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297-302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Jin J, Daniel JL, Kunapuli SP (1998). "Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets.". J. Biol. Chem. 273 (4): 2030-4. PMID 9442040.
• Hall RA, Ostedgaard LS, Premont RT, et al. (1998). "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins.". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496-501. PMID 9671706.
• Sabala P, Czajkowski R, Przybyłek K, et al. (2001). "Two subtypes of G protein-coupled nucleotide receptors, P2Y(1) and P2Y(2) are involved in calcium signalling in glioma C6 cells.". Br. J. Pharmacol. 132 (2): 393-402. doi:10.1038/sj.bjp.0703843. PMID 11159687.
• Yoshioka K, Saitoh O, Nakata H (2001). "Heteromeric association creates a P2Y-like adenosine receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7617-22. doi:10.1073/pnas.121587098. PMID 11390975.
• James G, Butt AM (2001). "Changes in P2Y and P2X purinoceptors in reactive glia following axonal degeneration in the rat optic nerve.". Neurosci. Lett. 312 (1): 33-6. PMID 11578839.
• Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1-3): 107-19. PMID 11690642.
• Czajkowski R, Lei L, Sabała P, Barańska J (2002). "ADP-evoked phospholipase C stimulation and adenylyl cyclase inhibition in glioma C6 cells occur through two distinct nucleotide receptors, P2Y(1) and P2Y(12).". FEBS Lett. 513 (2-3): 179-83. PMID 11904146.
• Aktas B, Hönig-Liedl P, Walter U, Geiger J (2002). "Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.". Biochem. Pharmacol. 64 (3): 433-9. PMID 12147294.
• Nurden P, Poujol C, Winckler J, et al. (2003). "Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system.". Blood 101 (4): 1400-8. doi:10.1182/blood-2002-02-0642. PMID 12393588.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440-7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
• Jagroop IA, Burnstock G, Mikhailidis DP (2003). "Both the ADP receptors P2Y1 and P2Y12, play a role in controlling shape change in human platelets.". Platelets 14 (1): 15-20. PMID 12623443.
• Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes.". J. Invest. Dermatol. 120 (6): 1007-15. PMID 12787128.
• Wang L, Ostberg O, Wihlborg AK, et al. (2003). "Quantification of ADP and ATP receptor expression in human platelets.". J. Thromb. Haemost. 1 (2): 330-6. PMID 12871508.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.