Betazole

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Betazole

Names
IUPAC name 2-(2H-Pyrazol-3-yl)ethanamine
Identifiers
CAS Number	105-20-4 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:59170 Y
ChEMBL	ChEMBL1201323 N
ChemSpider	7455 Y
ECHA InfoCard
PubChem CID	7741
UNII	1C065P542O Y
InChI InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8) Y Key: JXDFEQONERDKSS-UHFFFAOYSA-N Y InChI=1/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8) Key: JXDFEQONERDKSS-UHFFFAOYAY
SMILES n1ccc(n1)CCN
Properties
Chemical formula	C5H9N3
Molar mass	111.145 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
Infobox references

WikiDoc Resources for Betazole
Articles
Most recent articles on Betazole Most cited articles on Betazole Review articles on Betazole Articles on Betazole in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Betazole Images of Betazole Photos of Betazole Podcasts & MP3s on Betazole Videos on Betazole
Evidence Based Medicine
Cochrane Collaboration on Betazole Bandolier on Betazole TRIP on Betazole
Clinical Trials
Ongoing Trials on Betazole at Clinical Trials.gov Trial results on Betazole Clinical Trials on Betazole at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Betazole NICE Guidance on Betazole NHS PRODIGY Guidance FDA on Betazole CDC on Betazole
Books
Books on Betazole
News
Betazole in the news Be alerted to news on Betazole News trends on Betazole
Commentary
Blogs on Betazole
Definitions
Definitions of Betazole
Patient Resources / Community
Patient resources on Betazole Discussion groups on Betazole Patient Handouts on Betazole Directions to Hospitals Treating Betazole Risk calculators and risk factors for Betazole
Healthcare Provider Resources
Symptoms of Betazole Causes & Risk Factors for Betazole Diagnostic studies for Betazole Treatment of Betazole
Continuing Medical Education (CME)
CME Programs on Betazole
International
Betazole en Espanol Betazole en Francais
Business
Betazole in the Marketplace Patents on Betazole
Experimental / Informatics
List of terms related to Betazole

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Betazole is a histamine H₂ receptor agonist. Also known as Ametazole. Betazole hydrochloride is known as gastramine and histalog.

It has been used as a gastric stimulant to test for maximal production of gastric secretion activity The test can be used in diagnosis of diseases such as Zollinger-Ellison syndrome where there is excess acid production, in this case driven by over production of gastrin. The volume of acid secretion is measured following administration of betazole, diagnosis being secretion greater than 60% of the maximal acid secretion following betazole stimulation. This procedure can lead to complications and should be avoided in subjects with coronary artery disease It is also used in diagnosis of gastritis in association with a test for secretin activity

Betazole is used as a stimulant in preference to histamine because of its specificity for the H₂ receptor and its advantage of not generating the undesirable side effects that histamine would induce. It therefore does not require concomitant use of antihistaminic compounds to block the actions of histamine at other histamine receptor types.

Its action in stimulating histamine release can be of use when testing the effectiveness of H2 receptor blocking drugs such as Nizatidine.

References

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