Risperidone
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Synonyms / Brand Names: Risperidona, Risperidonum, Risperdal, Risperdal Consta, Risperdal M-Tab, Risperidal M-Tab, Risperin, Rispolept, Rispolin, Sequinan
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
Dosing and Administration
Schizophrenia
- Usual initial dose: Risperidone can be administered on either a BID or a QD schedule. In early clinical trials, Risperidone was generally administered at 1 mg BID initially, with increases in increments of 1 mg BID on the second and third day, as tolerated, to a target dose of 3 mg BID by the third day. Subsequent controlled trials have indicated that total daily Risperidone doses of up to 8 mg on a QD regimen are also safe and effective. However, regardless of which regimen is employed, in some patients a slower titration may be medically appropriate. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 1 week, since steady state for the active metabolite would not be achieved for approximately 1 week in the typical patient. When dosage adjustments are necessary, small dose increments/decrements of 1–2 mg are recommended.
Bipolar mania
- Usual dose: Risperidone should be administered on a once daily schedule, starting with 2 mg to 3 mg per day. Dosage adjustments, if indicated, should occur at intervals of not less than 24 hours and in dosage increments/decrements of 1 mg per day, as studied in the short-term, placebo-controlled trials. In these trials, short-term (3 week) anti-manic efficacy was demonstrated in a flexible dosage range of 1–6 mg per day. Risperidone doses higher than 6 mg per day were not studied.
FDA Package Insert Resources
Indications, Contraindications, Side Effects, Drug Interactions, etc.
Calculate Creatine Clearance
On line calculator of your patients Cr Cl by a variety of formulas.
Convert pounds to Kilograms
On line calculator of your patients weight in pounds to Kg for dosing estimates.
Publication Resources
Recent articles, WikiDoc State of the Art Review, Textbook Information
Trial Resources
Ongoing Trials, Trial Results
Guidelines & Evidence Based Medicine Resources
US National Guidelines, Cochrane Collaboration, etc.
Media Resources
Slides, Video, Images, MP3, Podcasts, etc.
Patient Resources
Discussion Groups, Handouts, Blogs, News, etc.
International Resources
en Español
FDA Package Insert Resources
Indications
Contraindications
Side Effects
Drug Interactions
Precautions
Overdose
Instructions for Administration
How Supplied
Pharmacokinetics and Molecular Data
FDA label
FDA on Risperidone
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Publication Resources
Most Recent Articles on Risperidone
Review Articles on Risperidone
Articles on Risperidone in N Eng J Med, Lancet, BMJ
WikiDoc State of the Art Review
Textbook Information on Risperidone
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Trial Resources
Ongoing Trials with Risperidone at Clinical Trials.gov
Trial Results with Risperidone
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Guidelines & Evidence Based Medicine Resources
US National Guidelines Clearinghouse on Risperidone
Cochrane Collaboration on Risperidone
Cost Effectiveness of Risperidone
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Media Resources
Powerpoint Slides on Risperidone
Images of Risperidone
Podcasts & MP3s on Risperidone
Videos on Risperidone
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Patient Resources
Patient Information from National Library of Medicine
Patient Resources on Risperidone
Discussion Groups on Risperidone
Patient Handouts on Risperidone
Blogs on Risperidone
Risperidone in the News
Risperidone in the Marketplace
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International Resources
Risperidone en Español
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The content of this page is taken from the FDA package insert for this drug and should not be edited.
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
