Hyperalgesia
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| Hyperalgesia Classification and external resources | |
| ICD-9 | 782.0 |
|---|---|
| DiseasesDB | 30788 |
| MeSH | D006930 |
|
WikiDoc Resources for Hyperalgesia | |
|
Articles | |
|---|---|
|
Most recent articles on Hyperalgesia Most cited articles on Hyperalgesia | |
|
Media | |
|
Powerpoint slides on Hyperalgesia | |
|
Evidence Based Medicine | |
|
Clinical Trials | |
|
Ongoing Trials on Hyperalgesia at Clinical Trials.gov Clinical Trials on Hyperalgesia at Google
| |
|
Guidelines / Policies / Govt | |
|
US National Guidelines Clearinghouse on Hyperalgesia
| |
|
Books | |
|
News | |
|
Commentary | |
|
Definitions | |
|
Patient Resources / Community | |
|
Patient resources on Hyperalgesia Discussion groups on Hyperalgesia Patient Handouts on Hyperalgesia Directions to Hospitals Treating Hyperalgesia Risk calculators and risk factors for Hyperalgesia
| |
|
Healthcare Provider Resources | |
|
Causes & Risk Factors for Hyperalgesia | |
|
Continuing Medical Education (CME) | |
|
International | |
|
| |
|
Businness | |
|
Experimental / Informatics | |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Hyperalgesia is an extreme sensitivity to pain, which in one form is caused by damage to nociceptors in the body's soft tissues.
Hyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioning studies have established that it is possible to experience a learned hyperalgesia of the latter, diffuse form. The focal form is typically associated with injury, and is divided into two subtypes:
- Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues.
- Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues.
Hyperalgesia is induced by Platelet Aggregating Factor (PAF) which comes about in an inflammatory or an allergic response. This seems to occur via immune cells interacting with the peripheral nervous system and releasing pain-producing chemicals (cytokines and chemokines) (see Marchand, Perretti, & McMahon, 2005).
One unusual cause of focal hyperalgesia is platypus venom.
Ikeda, Stark, Fischer, Wagner, Drdla, Jäger, et al. (2006) showed that stimulation of pain fibres in a pattern consistent with that from inflammation switched on a form of amplification in the spinal cord, long term potentiation. This occurred where the pain fibres contacted a pain pathway, the periaqueductal grey. Ikeda et al. argued that amplification in the spinal cord is another way of producing hyperalgesia.
References
- Ikeda, H., Stark, J., Fischer, H., Wagner, M., Drdla, R., Jäger, T., et al. (2006). Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science, 312, 1659-1662.
- Marchand, F., Perretti, M., & McMahon, S. B. (2005). Role of the immune system in chronic pain. Nature Reviews Neuroscience, 6, 521-532.
External links
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
