Mepyramine

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Mepyramine
Systematic (IUPAC) name
N1-(4-methoxybenzyl)- N2,N2-dimethyl- N1-(pyridin-2-yl)ethane- 1,2-diamine
Identifiers
CAS number	91-84-9
ATC code	R06AC01 D04 AA02
PubChem	?
Chemical data
Formula	C₁₇H₂₃N₃O
Mol. mass	285.38 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Mepyramine (INN, also known as pyrilamine) ^[1] is a first generation antihistamine, targeting the H₁ receptor. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.

It is used in over-the-counter combination products for colds and menstrual symptoms.^[2]

Side effects may include sedation/drowsiness, muscle weakness, and insomnia.^[3]

References

↑ Parsons, M. E. and Ganellin, C. R. (2006). "Histamine and its receptors". British Journal of Pharmacology 147: S127–S135. PMID 16402096.
↑ http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Cons/sep00cyp.cfm
↑ http://www.drugs.com/pdr/pyrilamine_maleate.html

External links

Mepyramine use in horses

v • d • e Antipruritics (D04)
Antihistamines for topical use	Thonzylamine - Mepyramine - Thenalidine - Tripelennamine - Chloropyramine - Promethazine - Tolpropamine - Dimetindene - Clemastine - Bamipine - Isothipendyl - Diphenhydramine - Chlorphenoxamine
Anesthetics for topical use	Lidocaine - Cinchocaine - Oxybuprocaine - Benzocaine - Quinisocaine - Tetracaine - Pramocaine

v • d • e Antihistamines (R06)
Aminoalkyl ethers	Bromazine/Bromodiphenhydramine • Carbinoxamine • Clemastine • Chlorphenoxamine • Diphenylpyraline • Diphenhydramine • Doxylamine • Orphenadrine • Phenyltoloxamine
Substituted alkylamines	Brompheniramine • Chlorphenamine • Dexbrompheniramine • Dexchlorpheniramine • Dimetindene • Pheniramine • Talastine
Substituted ethylenediamines	Chloropyramine • Histapyrrodine • Mepyramine • Methapyrilene • Tripelennamine (Pyribenzamine)
Phenothiazine derivatives	Alimemazine • Hydroxyethylpromethazine • Isothipendyl • Mequitazine • Methdilazine • Oxomemazine • Promethazine
Piperazine derivatives	Buclizine • Cetirizine • Chlorcyclizine • Cinnarizine • Cyclizine • Hydroxyzine • Levocetirizine • Meclizine • Niaprazine • Oxatomide
Others for systemic use	Antazoline • Azatadine • Bamipine • Cyproheptadine • Deptropine • Dimebon • Ebastine • Epinastine • Ketotifen • Mebhydrolin • Mizolastine • Phenindamine • Pimethixene • Pyrrobutamine • Rupatadine • Triprolidine • selective (Acrivastine • Astemizole • Azelastine • Desloratadine • Fexofenadine • Loratadine • Terfenadine)
For topical use	Bamipine • Chloropyramine • Chlorphenoxamine • Clemastine • Dimetindene • Diphenhydramine • Isothipendyl • Mepyramine • Promethazine • Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline • Azelastine
Other antiallergics	Emedastine • Epinastine • Ketotifen • Montelukast • Olopatadine