Triprolidine

Triprolidine
Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl- prop-1-enyl]pyridine
Identifiers
CAS number	486-12-4
ATC code	R06AX07
PubChem	5282443
DrugBank	APRD00306
Chemical data
Formula	C19H22N2
Mol. mass	278.391 g/mol
SMILES	eMolecules & PubChem
Physical data
Melt. point	60 °C (140 °F)
Solubility in water	500 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability	4% oral
Protein binding	90%
Metabolism	Hepatic (CYP2D6)
Half life	4 to 6 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	C (US)
Legal status	OTC (US)
Routes	Oral

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Overview

Triprolidine hydrochloride is an over-the-counter antihistamine. It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms. Like many over-the-counter antihistamines, the most common side effect is drowsiness.

Trade names

• Actidil
• Myidil
• Actifed (as a combination with pseudoephedrine) - no longer contains pseudoephedrine or triprolidine as of the end of 2006.

External links

• Information at WholeHealthMD.com