Phenyltoloxamine

Phenyltoloxamine
Systematic (IUPAC) name
N,N-dimethyl-2-(α-phenyl-O-tolyloxy)ethylamine
Identifiers
CAS number	92-12-6
ATC code	?
PubChem	7077
Chemical data
Formula	C17H21NO
Mol. mass	255.359
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	OTC(US)
Routes	oral

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Overview

Phenyltoloxamine is an antihistamine with sedative and analgesic effects. It is a member of the ethanolamine class of antihistaminergic agents and a potent anticholinergic.

Common use

Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine.

It also used to discourage abuse in certain opiate analgesics due its unpleasant side effects at high doses.

Adverse effects

Common adverse effects are those associated with most anticholinergics, effects are more pronounced in children and the elderly.

See also: anticholinergic

Availability

Phenyltoloxamine is available in most countries, though is rare in several western countries it remains widely used around the world, particularly in the developing world.

It is not a controlled substance; however some preparations contain opiates such as codeine or hydrocodone and are controlled, when used in preparations with acetaminophen is generally over the counter.

Phenyltoloxamine is sold under wide variety of preparations, brand names and dosages around the world:

• Ed-Flex, Dologesic, Flextra-650, Novagesic, Phenylgesic - North America
• Codipront - Europe/South America

Cost Effectiveness of Phenyltoloxamine

| group5 = Clinical Trials Involving Phenyltoloxamine | list5 = Ongoing Trials on Phenyltoloxamine at Clinical Trials.gov • Trial results on Phenyltoloxamine • Clinical Trials on Phenyltoloxamine at Google

| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Phenyltoloxamine | list6 = US National Guidelines Clearinghouse on Phenyltoloxamine • NICE Guidance on Phenyltoloxamine • NHS PRODIGY Guidance • FDA on Phenyltoloxamine • CDC on Phenyltoloxamine

| group7 = Textbook Information on Phenyltoloxamine | list7 = Books and Textbook Information on Phenyltoloxamine

| group8 = Pharmacology Resources on Phenyltoloxamine | list8 = AND (Dose)}} Dosing of Phenyltoloxamine • AND (drug interactions)}} Drug interactions with Phenyltoloxamine • AND (side effects)}} Side effects of Phenyltoloxamine • AND (Allergy)}} Allergic reactions to Phenyltoloxamine • AND (overdose)}} Overdose information on Phenyltoloxamine • AND (carcinogenicity)}} Carcinogenicity information on Phenyltoloxamine • AND (pregnancy)}} Phenyltoloxamine in pregnancy • AND (pharmacokinetics)}} Pharmacokinetics of Phenyltoloxamine •

| group9 = Genetics, Pharmacogenomics, and Proteinomics of Phenyltoloxamine | list9 = AND (pharmacogenomics)}} Genetics of Phenyltoloxamine • AND (pharmacogenomics)}} Pharmacogenomics of Phenyltoloxamine • AND (proteomics)}} Proteomics of Phenyltoloxamine

| group10 = Newstories on Phenyltoloxamine | list10 = Phenyltoloxamine in the news • Be alerted to news on Phenyltoloxamine • News trends on Phenyltoloxamine</small>

| group11 = Commentary on Phenyltoloxamine | list11 = Blogs on Phenyltoloxamine

| group12 = Patient Resources on Phenyltoloxamine | list12 = Patient resources on Phenyltoloxamine • Discussion groups on Phenyltoloxamine • Patient Handouts on Phenyltoloxamine • Directions to Hospitals Treating Phenyltoloxamine • Risk calculators and risk factors for Phenyltoloxamine

| group13 = Healthcare Provider Resources on Phenyltoloxamine | list13 = Symptoms of Phenyltoloxamine • Causes & Risk Factors for Phenyltoloxamine • Diagnostic studies for Phenyltoloxamine • Treatment of Phenyltoloxamine

| group14 = Continuing Medical Education (CME) Programs on Phenyltoloxamine | list14 = CME Programs on Phenyltoloxamine

| group15 = International Resources on Phenyltoloxamine | list15 = Phenyltoloxamine en Espanol • Phenyltoloxamine en Francais

| group16 = Business Resources on Phenyltoloxamine | list16 = Phenyltoloxamine in the Marketplace • Patents on Phenyltoloxamine

| group17 = Informatics Resources on Phenyltoloxamine | list17 = List of terms related to Phenyltoloxamine

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