Thyrotropin-releasing hormone
You don't need to be Editor-In-Chief to add or edit content to WikiDoc. You can begin to add to or edit text on this WikiDoc page by clicking on the edit button at the top of this page. Next enter or edit the information that you would like to appear here. Once you are done editing, scroll down and click the Save page button at the bottom of the page.
| |
| Structural formula of TRH | |
| thyrotropin-releasing hormone
| |
| Identifiers | |
| Symbol | TRH |
| Entrez | 7200 |
| HUGO | 12298 |
| OMIM | 275120 |
| RefSeq | NM_007117 |
| UniProt | P20396 |
| Other data | |
| Locus | Chr. 3 q13.3-q21 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-525-6884
Please Join in Editing This Page and Apply to be an Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF), thyroliberin or protirelin, is a tripeptide hormone that stimulates the release of thyroid-stimulating hormone and prolactin by the anterior pituitary.
Production
TRH is produced by the hypothalamus, near the paraventricular nucleus.[1]
It travels across the median eminence to the pituitary via the hypophyseal portal system. It is released from cells called thyrotropes.[1]
In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets.
History
The sequence of TRH was first determined and the hormone synthesized by Roger Guillemin and Andrew V. Schally in 1969.[1][1]
Chemical properties
Its molecular weight is 359.5 Da.
Its structure is: (pyro)Glu-His-Pro-NH2
Clinical significance
It is used in pharmacology (brand name Relefact TRH®) to test the response of the anterior pituitary gland.
Medical preparations of TRH are used in diagnostic tests of thyroid disorders and in acromegaly.
In 1998, a recombinant form of the hormone was approved by FDA, Thyrogen® (thyrotropin alfa), and is used in the detection of residual or recurrent thyroid cancer. (http://www.fda.gov/Cder/consumerinfo/druginfo/thyrogen.HTM)
See also
References
Peptides: neuropeptides | |
|---|---|
| Hypothalamic | Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) |
| Gastrointestinal hormones | Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide |
| Other hormones | Vasopressin - Calcitonin - |
| Other | Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide |
bg:Тиреотропин-освобождаващ хормон de:Thyreoliberin fr:Hormone thyréotrope it:TRH (ormone) nl:TRH ja:甲状腺刺激ホルモン放出ホルモンsl:Tiroliberin sr:Тиреотропин ослобађајући хормон
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
