Calcitonin gene-related peptide
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| calcitonin-related polypeptide, beta
| |
| Identifiers | |
| Symbol | CALCB |
| Alt. Symbols | CALC2 |
| Entrez | 797 |
| HUGO | 1438 |
| OMIM | 114160 |
| RefSeq | NM_000728 |
| UniProt | P10092 |
| Other data | |
| Locus | Chr. 11 p14.2-p12 |
Calcitonin gene related peptide (CGRP) is derived, with calcitonin, from the CT/CGRP gene located on chromosome 11. CGRP is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known.
CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide is the brain. This effect was found to be antagonised by capsazepine.[1] CGRP is also currently a major target of research in regards to factors effecting the onset of migrane headaches.
External Links
References
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Peptides: neuropeptides | |
|---|---|
| Hypothalamic | Somatostatin - CRH - GnRH - GHRH - Orexins - TRH - POMC (ACTH, MSH, Lipotropin) |
| Gastrointestinal hormones | Cholecystokinin - Gastric inhibitory polypeptide - Gastrin - Motilin - Secretin - Vasoactive intestinal peptide |
| Other hormones | Vasopressin - Calcitonin - |
| Other | Angiotensin - Bombesin/Neuromedin B - Calcitonin gene-related peptide - Carnosine - Delta sleep-inducing peptide - FMRFamide - Galanin - Gastrin releasing peptide - Kinins (Bradykinin, Tachykinins ) - Neuromedin (B, N, U) - Neuropeptide Y - Neurophysins - Neurotensin - Opioid peptide - Pancreatic polypeptide - Pituitary adenylate cyclase activating peptide |
